UniProt Q9GZZ9
Ubiquitin-like modifier-activating enzyme 5 (Q9GZZ9)
Ubiquitin-like modifier-activating enzyme 5 (UniProt Q9GZZ9): 18 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9GZZ9
- Protein
- Ubiquitin-like modifier-activating enzyme 5
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 29 · 4 records with a druggable one
Structures
19 records of Q9GZZ9 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3GUC | Human Ubiquitin-activating Enzyme 5 in Complex with AMPPNP | x-ray diffraction | A, B | — | — |
| 3GUC | Human ubiquitin-activating enzyme 5 in complex with amppnp | x-ray diffraction | A, B | — | — |
| 3H8V | Human Ubiquitin-activating Enzyme 5 in Complex with ATP | x-ray diffraction | A, B | — | — |
| 3H8V | Human ubiquitin-activating enzyme 5 in complex with ATP | x-ray diffraction | A, B | — | — |
| 5IAA | Crystal structure of human UBA5 in complex with UFM1 | x-ray diffraction | A, B | ZN | 6 (best 0.67) |
| 5IAA | Crystal structure of human UBA5 in complex with UFM1 | x-ray diffraction | A, B | — | — |
| 5L95 | Crystal structure of human UBA5 in complex with UFM1 and AMP | x-ray diffraction | A, B | AMP, ZN | — |
| 5L95 | Crystal structure of human UBA5 in complex with UFM1 and AMP | x-ray diffraction | A, B | AMP, ZN | — |
| 6H77 | E1 enzyme for ubiquitin like protein activation in complex with UBL | x-ray diffraction | A, B, C, D | ATP, MG, ZN | — |
| 6H77 | E1 enzyme for ubiquitin like protein activation in complex with ubl | x-ray diffraction | A, B, C, D | ATP, MG, ZN | — |
| 6H78 | E1 enzyme for ubiquitin like protein activation. | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | ATP, MG, ZN, CL | 20 (best 0.84) |
| 6H78 | E1 enzyme for ubiquitin like protein activation. | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | ATP, MG, ZN, CL | — |
| 6H8C | Structure of the human GABARAPL2 protein in complex with the UBA5 LIR motif | solution nmr | B | — | — |
| 6H8C | Structure of the human GABARAPL2 protein in complex with the UBA5 lir motif | solution nmr | B | — | — |
| 7NVK | Crystal structure of UBA5 fragment fused to the N-terminus of UFC1 | x-ray diffraction | AAA | — | 1 (best 0.35) |
| 7NW1 | Crystal structure of UFC1 in complex with UBA5 | x-ray diffraction | CCC, FFF | — | 1 (best 0.56) |
| 7OVC | Structure of the human UFC1 protein in complex with the UBA5 C-terminal UFC1-binding motif. | solution nmr | B | — | — |
| 7OVC | Structure of the human UFC1 protein in complex with the UBA5 C- terminal UFC1-binding motif. | solution nmr | B | — | — |
| Q9GZZ9 | AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme 5 (Q9GZZ9) | predicted | A | — | 1 (best 0.66) |
Ligands
Experiment against prediction
- 6H77 chain C against the predicted model Q9GZZ9: TM-score 1.00, RMSD 0.42 Å
- 6H77 chain C against the predicted model Q9GZZ9: TM-score 1.00, RMSD 0.42 Å
- 6H77 chain B against the predicted model Q9GZZ9: TM-score 0.99, RMSD 0.47 Å
- 6H77 chain B against the predicted model Q9GZZ9: TM-score 0.99, RMSD 0.47 Å
- 6H78 chain M against the predicted model Q9GZZ9: TM-score 0.99, RMSD 0.49 Å
- 6H78 chain M against the predicted model Q9GZZ9: TM-score 0.99, RMSD 0.49 Å
- 6H78 chain F against the predicted model Q9GZZ9: TM-score 0.99, RMSD 0.49 Å
- 6H78 chain F against the predicted model Q9GZZ9: TM-score 0.99, RMSD 0.49 Å
- 6H78 chain O against the predicted model Q9GZZ9: TM-score 0.99, RMSD 0.53 Å
- 6H78 chain D against the predicted model Q9GZZ9: TM-score 0.99, RMSD 0.57 Å
Elsewhere
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