Research workbench
Crystal structure of AP2 MU2 - FCHO2 chimera (GST cleaved)
Analyse Crystal structure of AP2 MU2 - FCHO2 chimera (GST cleaved) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7OI5
- Type
- protein
- Length
- 573 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-2 complex subunit MU,F-bar domain only protein 2
- UniProt
- P84092, Q0JRZ9
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Ap-2 complex subunit MU,F-bar domain only protein 2 | protein | 292 | 4% helix, 51% strand | P84092, Q0JRZ9 |
| D | Ap-2 complex subunit MU,F-bar domain only protein 2 | protein | 281 | 3% helix, 52% strand | P84092, Q0JRZ9 |
Ligands and binding sites
- GOL · Glycerol · additive · 3 copies · chains B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 973 | 0.77 | 0.79 | 102 | empty |
| 2 | 163 | 0.44 | 0.75 | 21 | empty |
| 3 | 84 | 0.31 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- B–D · 805 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7OI5 · Crystal structure of AP2 Mu2 - FCHO2 chimera (GST cleaved) · the same entry in another collection · chain B against B, TM-score 1.00
- P84092 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit mu (P84092) · a predicted model of the same protein · chain D against A, TM-score 0.87
- Q0JRZ9 · AlphaFold monomer V2.0 prediction for F-bar domain only protein 2 (Q0JRZ9) · a predicted model of the same protein · chain D against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84092
- Every structure of UniProt Q0JRZ9
- Elsewhere: RCSB PDB 7OI5 · PDBe 7OI5 · UniProt P84092 · UniProt Q0JRZ9
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