UniProt P84092
AP-2 complex subunit mu (P84092)
AP-2 complex subunit mu (UniProt P84092): 49 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P84092
- Protein
- AP-2 complex subunit mu
- Experimental structures
- 49
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 30 · 4 records with a druggable one
Structures
50 records of P84092 in the MolNFT archive: 49 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BW8 | MU2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with EGFR internalization… | x-ray diffraction | A | — | — |
| 1BW8 | MU2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with EGFR internalization… | x-ray diffraction | A | — | — |
| 1BXX | MU2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with TGN38 internalization… | x-ray diffraction | A | — | — |
| 1BXX | MU2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with TGN38 internalization… | x-ray diffraction | A | — | — |
| 1I31 | MU2 adaptin subunit (AP50) of AP2 clathrin adaptor, complexed with EGFR internalization peptide… | x-ray diffraction | A | — | — |
| 1I31 | MU2 adaptin subunit (AP50) of AP2 clathrin adaptor, complexed with EGFR internalization peptide… | x-ray diffraction | A | — | — |
| 2BP5 | MU2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with non-canonical… | x-ray diffraction | M | — | — |
| 2BP5 | MU2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with non-canonical… | x-ray diffraction | M | — | — |
| 2JKR | AP2 CLATHRIN ADAPTOR CORE with Dileucine peptide RM(phosphoS)QIKRLLSE | x-ray diffraction | M, U | — | — |
| 2JKR | AP2 clathrin adaptor core with dileucine peptide rm( PHOSPHOS)QIKRLLSE | x-ray diffraction | M, U | — | — |
| 2JKT | AP2 CLATHRIN ADAPTOR CORE with CD4 Dileucine peptide RM(phosphoS) EIKRLLSE Q to E mutant | x-ray diffraction | M, U | — | — |
| 2JKT | AP2 clathrin adaptor core with CD4 dileucine peptide rm( PHOSPHOS)EIKRLLSE Q to E mutant | x-ray diffraction | M, U | — | — |
| 2PR9 | Mu2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with GABAA receptor-gamma2… | x-ray diffraction | A | — | — |
| 2PR9 | MU2 adaptin subunit (AP50) of AP2 adaptor (second domain), complexed with gabaa receptor-GAMMA2… | x-ray diffraction | A | — | — |
| 2VGL | AP2 clathrin adaptor core | x-ray diffraction | M | — | — |
| 2VGL | AP2 clathrin adaptor core | x-ray diffraction | M | — | — |
| 2XA7 | AP2 clathrin adaptor core in active complex with cargo peptides | x-ray diffraction | M | — | — |
| 2XA7 | AP2 clathrin adaptor core in active complex with cargo peptides | x-ray diffraction | M | — | — |
| 3H85 | Molecular basis for the association of PIPKI gamma-p90 with the clathrin adaptor AP-2 | x-ray diffraction | A | — | — |
| 3H85 | Molecular basis for the association of pipki gamma-P90 with the clathrin adaptor ap-2 | x-ray diffraction | A | — | — |
| 3ML6 | a complex between Dishevelled2 and clathrin adaptor AP-2 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3ML6 | A complex between DISHEVELLED2 and clathrin adaptor ap-2 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4UQI | AP2 controls clathrin polymerization with a membrane-activated switch | x-ray diffraction | M | — | — |
| 4UQI | AP2 controls clathrin polymerization with a membrane-activated switch | x-ray diffraction | M | — | — |
| 5C7Z | AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide | x-ray diffraction | A | — | 3 (best 0.47) |
| 5C7Z | AP2 MU2 adaptin C-terminal domain complexed with integrin alpha-4 peptide | x-ray diffraction | A | — | — |
| 5FPI | Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4… | x-ray diffraction | A | — | — |
| 5FPI | MU2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with integrin ALPHA4… | x-ray diffraction | A | — | — |
| 5WRK | Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y608 peptide | x-ray diffraction | A | NI | 2 (best 0.38) |
| 5WRK | MU2 subunit of the clathrin adaptor complex AP2 in complex with irs-1 Y608 peptide | x-ray diffraction | A | NI | — |
| 5WRL | Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y628 peptide | x-ray diffraction | A | — | 2 (best 0.42) |
| 5WRL | MU2 subunit of the clathrin adaptor complex AP2 in complex with irs-1 Y628 peptide | x-ray diffraction | A | — | — |
| 5WRM | MU2 subunit of the clathrin adaptor complex AP2 in complex with irs-1 Y658 peptide | x-ray diffraction | A | — | — |
| 6QH5 | AP2 clathrin adaptor MU2T156-phosphorylated core in closed conformation | x-ray diffraction | N, M | — | — |
| 6QH6 | AP2 clathrin adaptor core with two cargo peptides in open+ conformation | x-ray diffraction | N | — | — |
| 6RH6 | Solution structure and 1H, 13C and 15N chemical shift assignments for the complex of NECAP1 phear… | solution nmr | B | — | — |
| 6YAE | AP2 core in physiological buffer | electron microscopy | M | — | — |
| 6YAF | AP2 on a membrane containing tyrosine-based cargo peptide | electron microscopy | M | — | — |
| 6YAF | AP2 on a membrane containing tyrosine-based cargo peptide | electron microscopy | M | — | — |
| 6YAH | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo… | electron microscopy | M | — | — |
| 6YAH | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo… | electron microscopy | M | — | — |
| 7OFP | Apo Structure of Mu2 Adaptin Subunit (Ap50) Of AP2 Clathrin Adaptor | x-ray diffraction | A, B | — | 3 (best 0.74) |
| 7OFP | Apo structure of MU2 adaptin subunit (AP50) of AP2 clathrin adaptor | x-ray diffraction | A, B | — | — |
| 7OHO | Crystal structure of AP2 FCHO2 chimera | x-ray diffraction | MMM | — | 12 (best 0.85) |
| 7OHZ | Crystal structure of AP2 Mu2 - FCHO2 chimera (His6-tagged) | x-ray diffraction | B, A | — | 5 (best 0.78) |
| 7OHZ | Crystal structure of AP2 MU2 - FCHO2 chimera (HIS6-tagged) | x-ray diffraction | B, A | — | — |
| 7OI5 | Crystal structure of AP2 Mu2 - FCHO2 chimera (GST cleaved) | x-ray diffraction | B, D | — | 3 (best 0.77) |
| 7OI5 | Crystal structure of AP2 MU2 - FCHO2 chimera (GST cleaved) | x-ray diffraction | B, D | — | — |
| 7Z5C | Chimera of AP2 with FCHO2 linker domain as a fusion on CMU2 subunit | electron microscopy | M | — | — |
| P84092 | AlphaFold monomer V2.0 prediction for ap-2 complex subunit mu (P84092) | predicted | A | — | — |
Ligands
- NI · Nickel (II) ion · in 2 records
Experiment against prediction
- 3H85 chain A against the predicted model P84092: TM-score 0.96, RMSD 1.31 Å
- 3H85 chain A against the predicted model P84092: TM-score 0.96, RMSD 1.31 Å
- 2PR9 chain A against the predicted model P84092: TM-score 0.95, RMSD 1.36 Å
- 2PR9 chain A against the predicted model P84092: TM-score 0.95, RMSD 1.36 Å
- 5FPI chain A against the predicted model P84092: TM-score 0.95, RMSD 1.37 Å
- 5FPI chain A against the predicted model P84092: TM-score 0.95, RMSD 1.37 Å
- 5C7Z chain A against the predicted model P84092: TM-score 0.95, RMSD 1.37 Å
- 5C7Z chain A against the predicted model P84092: TM-score 0.95, RMSD 1.37 Å
- 5WRK chain A against the predicted model P84092: TM-score 0.95, RMSD 1.38 Å
- 5WRK chain A against the predicted model P84092: TM-score 0.95, RMSD 1.38 Å
Elsewhere
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