Research workbench
14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-043
Analyse 14-3-3 sigma with RELA/P65 binding site PS45 and covalently bound TCF521-043 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7O34
- Type
- protein
- Length
- 234 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein sigma; Transcription factor P65
- UniProt
- P31947, Q04206
- Ligands
- V0Q, MG
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein sigma | protein | 226 | 83% helix, 0% strand | P31947 |
| P | Transcription factor P65 | protein | 8 | 0% helix, 0% strand | Q04206 |
Ligands and binding sites
- V0Q · [4-(4-ethylpiperazin-1-yl)sulfonylphenyl]methanol · ligand · chains A, P
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 150 | 0.51 | 0.79 | 22 | V0Q |
Interfaces
1 interface between chains.
- A–P · 552 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).
Compared structures
- 7O34 · 14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-043 · the same entry in another collection · chain A against A, TM-score 1.00
- P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31947
- Every structure of UniProt Q04206
- Elsewhere: RCSB PDB 7O34 · PDBe 7O34 · UniProt P31947 · UniProt Q04206
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