Research workbench
Homology model of the in situ actomyosin complex from the a-band of mouse psoas muscle sarcomere in the rigor state
Analyse Homology model of the in situ actomyosin complex from the a-band of mouse psoas… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NEP
- Type
- protein
- Length
- 7,276 residues
- Chains
- 21
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle; Tropomyosin alpha-1 chain; Myosin-4; Myosin light chain…
- UniProt
- P68134, P58771, Q5SX39, P05977, P97457
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 6 distinct chains · 58% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K | Actin, alpha skeletal muscle | protein | 374 | 39% helix, 19% strand | P68134 |
| P, Q | Tropomyosin alpha-1 chain | protein | 233 | 99% helix, 0% strand | P58771 |
| T, U | Tropomyosin alpha-1 chain | protein | 243 | 99% helix, 0% strand | P58771 |
| L, M | Myosin-4 | protein | 813 | 45% helix, 15% strand | Q5SX39 |
| N, O | Myosin light chain 1/3, skeletal muscle isoform | protein | 148 | 49% helix, 8% strand | P05977 |
| R, S | Myosin regulatory light chain 2, skeletal muscle isoform | protein | 144 | 51% helix, 5% strand | P97457 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 939 | 0.84 | 0.86 | 96 | empty |
| 2 | 928 | 0.79 | 0.82 | 87 | empty |
| 3 | 642 | 0.79 | 0.84 | 61 | empty |
| 4 | 130 | 0.79 | 0.97 | 36 | empty |
| 5 | 134 | 0.78 | 0.96 | 36 | empty |
Interfaces
50 interfaces between chains.
- T–U · 6401 Ų buried · 44 hydrogen bonds · protein-protein
- P–Q · 6154 Ų buried · 42 hydrogen bonds · protein-protein
- L–R · 1967 Ų buried · 17 hydrogen bonds · protein-protein
- M–S · 1934 Ų buried · 18 hydrogen bonds · protein-protein
- L–N · 1563 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 7NEP · Homology model of the in situ actomyosin complex from the A-band of mouse psoas muscle… · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68134
- Every structure of UniProt P58771
- Every structure of UniProt Q5SX39
- Every structure of UniProt P05977
- Every structure of UniProt P97457
- Elsewhere: RCSB PDB 7NEP · PDBe 7NEP · UniProt P68134 · UniProt P58771 · UniProt Q5SX39 · UniProt P05977 · UniProt P97457
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