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ATAD2 bromodomain complexed with histone H4K5AC (res 1-10) ligand

Analyse ATAD2 bromodomain complexed with histone H4K5AC (res 1-10) ligand in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7M98
Type: protein
Length: 140 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATPase family aaa domain-containing protein 2; Histone H4
EC: 3.6.1.-
UniProt: Q6PL18, P62805

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATPase family aaa domain-containing protein 2 (EC 3.6.1.-)	protein	133	74% helix, 0% strand	Q6PL18
B	Histone H4	protein	7	0% helix, 0% strand	P62805

Interfaces

1 interface between chains.

A–B · 465 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (acetylation).

Compared structures

7M98 · ATAD2 bromodomain complexed with histone H4K5ac (res 1-10) ligand · the same entry in another collection · chain A against A, TM-score 1.00
Q6PL18 · AlphaFold monomer V2.0 prediction for ATPase family aaa domain- containing protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.95
P62805 · AlphaFold monomer V2.0 prediction for histone H4 (P62805) · a predicted model of the same protein · chain B against A, TM-score 0.36

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6PL18
Every structure of UniProt P62805
Elsewhere: RCSB PDB 7M98 · PDBe 7M98 · UniProt Q6PL18 · UniProt P62805

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