UniProt Q6PL18
ATPase family AAA domain-containing protein 2 (Q6PL18)
ATPase family AAA domain-containing protein 2 (UniProt Q6PL18), EC 3.6.1.-, 3.6.1.3: 191 experimental structures and 1 predicted model on GenesisL1, 83 ligands bound, 139 pockets. Binding sites, druggability and experiment…
- UniProt
- Q6PL18
- Protein
- ATPase family AAA domain-containing protein 2
- EC
- 3.6.1.-, 3.6.1.3
- Experimental structures
- 191
- Predicted models
- 1
- Ligands
- 83
- Pockets
- 139 · 27 records with a druggable one
Structures
192 records of Q6PL18 in the MolNFT archive: 191 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3DAI | Crystal structure of the bromodomain of the human ATAD2 | x-ray diffraction | A | — | — |
| 3DAI | Crystal structure of the bromodomain of the human ATAD2 | x-ray diffraction | A | — | — |
| 4QSP | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSP | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSQ | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) with… | x-ray diffraction | A | — | — |
| 4QSQ | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) with… | x-ray diffraction | A | — | — |
| 4QSR | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) with… | x-ray diffraction | A | — | — |
| 4QSR | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) with… | x-ray diffraction | A | — | — |
| 4QSS | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSS | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QST | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QST | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSU | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSU | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSV | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSV | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSW | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSW | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSX | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QSX | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2) in… | x-ray diffraction | A | — | — |
| 4QUT | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2)… | x-ray diffraction | A | — | — |
| 4QUT | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2)… | x-ray diffraction | A | — | — |
| 4QUU | Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2)… | x-ray diffraction | A | — | — |
| 4QUU | Structure of the bromodomain of human ATPase family aaa domain- containing protein 2 (ATAD2)… | x-ray diffraction | A | — | — |
| 4TT2 | Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5Ac peptide | x-ray diffraction | A | — | — |
| 4TT2 | Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5AC peptide | x-ray diffraction | A | — | — |
| 4TT4 | Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide | x-ray diffraction | A, B | — | — |
| 4TT4 | Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14AC peptide | x-ray diffraction | A, B | — | — |
| 4TT6 | Crystal structure of ATAD2A bromodomain double mutant N1063A-Y1064A in apo form | x-ray diffraction | A | — | — |
| 4TT6 | Crystal structure of ATAD2A bromodomain double mutant N1063A-Y1064A in apo form | x-ray diffraction | A | — | — |
| 4TTE | Crystal structure of ATAD2A bromodomain complexed with methyl… | x-ray diffraction | A | — | — |
| 4TTE | Crystal structure of ATAD2A bromodomain complexed with methyl 3-amino… | x-ray diffraction | A | — | — |
| 4TU4 | Crystal structure of ATAD2A bromodomain complexed with… | x-ray diffraction | A | — | — |
| 4TU4 | Crystal structure of ATAD2A bromodomain complexed with 3-(3,5… | x-ray diffraction | A | — | — |
| 4TU6 | Crystal structure of apo ATAD2A bromodomain with N1064 alternate conformation | x-ray diffraction | A, B, C, D | — | — |
| 4TU6 | Crystal structure of apo ATAD2A bromodomain with N1064 alternate conformation | x-ray diffraction | A, B, C, D | — | — |
| 4TYL | Fragment-Based Screening of the Bromodomain of ATAD2 | x-ray diffraction | A | — | — |
| 4TYL | Fragment-based screening of the bromodomain of ATAD2 | x-ray diffraction | A | — | — |
| 4TZ2 | Fragment-Based Screening of the Bromodomain of ATAD2 | x-ray diffraction | A | — | — |
| 4TZ2 | Fragment-based screening of the bromodomain of ATAD2 | x-ray diffraction | A | — | — |
| 4TZ8 | Structure of human ATAD2 bromodomain bound to fragment inhibitor | x-ray diffraction | A | — | — |
| 4TZ8 | Structure of human ATAD2 bromodomain bound to fragment inhibitor | x-ray diffraction | A | — | — |
| 5A5O | Crystal structure of human ATAD2 bromodomain in complex with 3-methyl- 1,2-dihydroquinolin-2-one | x-ray diffraction | A | J5I, SO4 | 1 (best 0.48) |
| 5A5O | Crystal structure of human ATAD2 bromodomain in complex with 3-methyl-1,2-dihydroquinolin-2-one | x-ray diffraction | A | — | — |
| 5A5P | Crystal structure of human ATAD2 bromodomain in complex with… | x-ray diffraction | A | — | — |
| 5A5P | Crystal structure of human ATAD2 bromodomain in complex with… | x-ray diffraction | A | — | — |
| 5A5Q | Crystal structure of human ATAD2 bromodomain in complex with 3-methyl… | x-ray diffraction | A | 6XC, SO4 | 1 (best 0.48) |
| 5A5Q | Crystal structure of human ATAD2 bromodomain in complex with… | x-ray diffraction | A | — | — |
| 5A5R | Crystal structure of human ATAD2 bromodomain in complex with 5-5… | x-ray diffraction | A | — | — |
| 5A5R | Crystal structure of human ATAD2 bromodomain in complex with… | x-ray diffraction | A | — | — |
| 5A81 | Crystal structure of human ATAD2 bromodomain in complex with 8-(3R,4R)… | x-ray diffraction | A | — | — |
| 5A81 | Crystal structure of human ATAD2 bromodomain in complex with… | x-ray diffraction | A | — | — |
| 5EPB | Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49 | x-ray diffraction | A | 5QW, SO4 | — |
| 5EPB | Crystal structure of the bromodomain of human ATAD2 in complex with compound 49 | x-ray diffraction | A | — | — |
| 5F36 | Crystal structure of the bromodomain of human ATAD2 in complex with Compound A12 | x-ray diffraction | A | 5UE, SO4, CL | — |
| 5F36 | Crystal structure of the bromodomain of human ATAD2 in complex with compound A12 | x-ray diffraction | A | — | — |
| 5F3A | Crystal structure of the bromodomain of human ATAD2 in complex with Compound A14 | x-ray diffraction | A | SO4, 5U9 | 1 (best 0.47) |
| 5F3A | Crystal structure of the bromodomain of human ATAD2 in complex with compound A14 | x-ray diffraction | A | — | — |
| 5LJ0 | Crystal structure of human ATAD2 bromodomain in complex with… | x-ray diffraction | A | 6XX, SO4 | 1 (best 0.49) |
| 5LJ0 | Crystal structure of human ATAD2 bromodomain in complex with 8-(((3R… | x-ray diffraction | A | 6XX, SO4 | — |
132 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 128 records
- CL · Chloride ion · in 20 records
- ADP · Adenosine-5'-diphosphate · in 4 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- 6XX · 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one · in 2 records
- 93L · (1R,9S)-13-[[3-methyl-8-[(1-methylpiperidin-4-yl) amino]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]carbonyl]-11,13-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4,6-trien-10-one · in 2 records
- 963 · (1R,9S)-13-(3,5-dimethoxy-4-oxidanyl-phenyl)carbonyl-11,13-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4,6-trien-10-one · in 2 records
- FZB · 3-methyl-8-((8-methyl-8-azabicyclooctan-3-yl)amino)-1, 7-naphthyridin-2(1H)-one · in 2 records
- FZH · 8-[[(1~{S},2~{R},3~{R},5~{R})-2-[2-[1,1-bis(oxidanylidene)thian-4-yl]ethyl]-8-azabicyclo[3.2.1]octan-3-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1~{H}-quinolin-2-one · in 2 records
- G6Z · 1-azanyl-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-1,3-thiazol-2-yl]cyclobutane-1-carboxamide · in 2 records
- G7B · 2-azanyl-~{N}-(4-ethanoyl-1,3-thiazol-2-yl)-2-methyl-propanamide · in 2 records
- G7E · ~{N}-[4-ethanoyl-5-(4-morpholin-4-ylcarbonylphenyl)-1, 3-thiazol-2-yl]piperazine-2-carboxamide · in 2 records
- GWA · ~{N}-(3-acetamidophenyl)-2-methoxy-ethanamide · in 2 records
- GX4 · cyclopropyl-[4-(4-fluorophenyl)piperazin-1-yl]methanone · in 2 records
- JMM · [4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl) methanone · in 2 records
- K3D · 4-acetyl-N-ethylpiperazine-1-carboxamide · in 2 records
- KVT · ~{N}-[3-(azepan-1-ylsulfonyl)-4-methyl-phenyl]-2-[4,4-dimethyl-2,5-bis(oxidanylidene)imidazolidin-1-yl]ethanamide · in 2 records
- KVZ · 2-[(4~{R})-2',5'-bis(oxidanylidene)spiro[2,3-dihydro-1~{H}-naphthalene-4,4'-imidazolidine]-1'-yl]-~{N}-[4-chloranyl-3-(dimethylsulfamoyl)phenyl]ethanamide · in 2 records
- KW5 · 2-[2,5-bis(oxidanylidene)imidazolidin-1-yl]-~{N}-[4-bromanyl-3-[(3~{S})-3-methylpiperidin-1-yl]sulfonyl-phenyl]ethanamide · in 2 records
- RGD · cyclobutyl[(2S,3aS,6aS)-6a-(2-hydroxyethyl)-2-(hydroxymethyl)hexahydro-5H-furo[2,3-c]pyrrol-5-yl]methanone · in 2 records
- RGM · (3aS,8S,9aS)-2-acetyl-10-methyl-2,3,6,8,9,9a-hexahydro-3a,8-epiminocyclohepta[1,2-c:4,5-c']dipyrrol-4(1H)-one · in 2 records
- RGV · (3as,8s,9as)-10-methyl-4-oxo-1,4,6,8,9,9A-hexahydro-3A, 8-epiminocyclohepta[1,2-C:4,5-c']dipyrrole-2(3H)-carbaldehyde · in 2 records
- RGY · (4r,4as,7as,9s)-3,10-dimethyl-5,6,7,7A,8,9-hexahydro-4H-4A,9-epiminopyrrolo[3',4':5,6]cyclohepta[1,2-D][1, 2]oxazol-4-ol · in 2 records
- RH4 · methyl (2R)-3-(furan-2-yl)-2-(pyridin-4-yl)propanoate · in 2 records
- RH7 · methyl (5aS,8aS,10S)-8,8a,9,10-tetrahydro-5H-5a,10-epoxypyrrolo[3',4':4,5]cyclohepta[1,2-b]pyrazine-7(6H)-carboxylate · in 2 records
- RHG · (3ar,8s,9as)-2-[(trifluoromethyl)sulfonyl]decahydro-3A, 8-epoxypyrrolo[3,4-c]azocine · in 2 records
- RHJ · cyclobutyl[(3aS,4R,5R,7S,8aS)-4,5-dihydroxyhexahydro-1H-3a,7-epoxycyclohepta[c]pyrrol-2(3H)-yl]methanone · in 2 records
- RHV · Ethyl N-[(2R)-2-(4-methylpyridin-2-yl) propanoyl]glycinate · in 2 records
- RHY · 1-[(4aS,7aS,9S)-3,4,7,7a,8,9-hexahydro-4a,9-epoxypyrrolo[3',4':4,5]cyclohepta[1,2-d]imidazol-6(5H)-yl]ethan-1-one · in 2 records
- RJ4 · (4aR,7aR,9R)-3,4,7,7a,8,9-hexahydro-4a,9-epoxypyrrolo[3',4':4,5]cyclohepta[1,2-d]imidazole-6(5H)-carbaldehyde · in 2 records
Experiment against prediction
- 5R4E chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.75 Å
- 5R4E chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.75 Å
- 6HIE chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.74 Å
- 6HI7 chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.75 Å
- 5QXI chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.75 Å
- 5QXI chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.75 Å
- 5QXW chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.76 Å
- 5QXW chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.76 Å
- 5A81 chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.77 Å
- 5A81 chain A against the predicted model Q6PL18: TM-score 0.97, RMSD 0.77 Å
Elsewhere
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