Research workbench
Full length ALPHA1 glycine receptor in presence of 0.1MM glycine
Analyse Full length ALPHA1 glycine receptor in presence of 0.1MM glycine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7M6N
- Type
- protein
- Length
- 1,805 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycine receptor subunit ALPHAZ1
- UniProt
- O93430
- Ligands
- GLY, NAG
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, E, B, C | Glycine receptor subunit ALPHAZ1 | protein | 361 | 39% helix, 26% strand | O93430 |
Ligands and binding sites
- GLY · Glycine · ligand · 5 copies · chains A, B, D, E, C
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A, D, E, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 798 | 0.80 | 0.83 | 81 | empty |
| 2 | 548 | 0.72 | 0.81 | 76 | empty |
| 3 | 413 | 0.68 | 0.80 | 52 | empty |
| 4 | 484 | 0.67 | 0.79 | 52 | empty |
| 5 | 487 | 0.67 | 0.78 | 56 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2449 Ų buried · 13 hydrogen bonds · protein-protein
- D–E · 2430 Ų buried · 11 hydrogen bonds · protein-protein
- D–C · 2425 Ų buried · 11 hydrogen bonds · protein-protein
- A–E · 2415 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 2411 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 5 glycan (disulfide, N-glycosylation).
Compared structures
- 7M6N · Full length alpha1 Glycine receptor in presence of 0.1mM Glycine · the same entry in another collection · chain C against C, TM-score 1.00
- O93430 · AlphaFold monomer V2.0 prediction for glycine receptor subunit ALPHAZ1 (O93430) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O93430
- Elsewhere: RCSB PDB 7M6N · PDBe 7M6N · UniProt O93430
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