UniProt O93430
Glycine receptor subunit alphaZ1 (O93430)
Glycine receptor subunit alphaZ1 (UniProt O93430): 60 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 489 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O93430
- Protein
- Glycine receptor subunit alphaZ1
- Experimental structures
- 60
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 489 · 25 records with a druggable one
Structures
61 records of O93430 in the MolNFT archive: 60 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6PLO | CryoEM structure of zebra fish alpha-1 glycine receptor YGF mutant bound with GABA in SMA,open state | electron microscopy | A, B, C, D, E | NAG, ABU | 20 (best 0.83) |
| 6PLO | Cryoem structure of zebra fish alpha-1 glycine receptor ygf mutant bound with GABA in SMA,OPEN state | electron microscopy | A, B, C, D, E | NAG, ABU | — |
| 6PLP | CryoEM structure of zebra fish alpha-1 glycine receptor YGF mutant bound with GABA in SMA… | electron microscopy | A, B, C, D, E | NAG, ABU | 20 (best 0.80) |
| 6PLP | Cryoem structure of zebra fish alpha-1 glycine receptor ygf mutant bound with GABA in sma… | electron microscopy | A, B, C, D, E | NAG, ABU | — |
| 6PLQ | CryoEM structure of zebra fish alpha-1 glycine receptor YGF mutant bound with GABA in SMA… | electron microscopy | A, B, C, D, E | NAG, ABU | 20 (best 0.80) |
| 6PLQ | Cryoem structure of zebra fish alpha-1 glycine receptor ygf mutant bound with GABA in sma… | electron microscopy | A, B, C, D, E | NAG, ABU | — |
| 6PLR | CryoEM structure of zebra fish alpha-1 glycine receptor bound with glycine in nanodisc… | electron microscopy | A, B, C, D, E | NAG, UNL, GLY | 20 (best 0.79) |
| 6PLR | Cryoem structure of zebra fish alpha-1 glycine receptor bound with glycine in nanodisc… | electron microscopy | A, B, C, D, E | NAG, UNL | — |
| 6PLS | CryoEM structure of zebra fish alpha-1 glycine receptor bound with taurine in nanodisc… | electron microscopy | A, B, C, D, E | NAG, TAU, UNL | 19 (best 0.81) |
| 6PLS | Cryoem structure of zebra fish alpha-1 glycine receptor bound with taurine in nanodisc… | electron microscopy | A, B, C, D, E | NAG, TAU, UNL | — |
| 6PLT | Cryoem structure of zebra fish alpha-1 glycine receptor bound with taurine in nanodisc, closed state | electron microscopy | A, E, D, C, B | NAG, UNL, TAU | — |
| 6PLU | CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in nanodisc, desensitized… | electron microscopy | A, B, C, D, E | NAG, ABU, UNL | 20 (best 0.81) |
| 6PLU | Cryoem structure of zebra fish alpha-1 glycine receptor bound with GABA in nanodisc, desensitized… | electron microscopy | A, B, C, D, E | NAG, ABU, UNL | — |
| 6PLV | CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in nanodisc, closed state | electron microscopy | A, B, C, D, E | NAG, UNL, ABU | 20 (best 0.82) |
| 6PLV | Cryoem structure of zebra fish alpha-1 glycine receptor bound with GABA in nanodisc, closed state | electron microscopy | A, B, C, D, E | NAG, UNL, ABU | — |
| 6PLW | Cryoem structure of zebra fish alpha-1 glycine receptor bound with GABA in sma, super-open state | electron microscopy | A, B, C, D, E | NAG, ABU | — |
| 6PLX | Cryoem structure of zebra fish alpha-1 glycine receptor bound with GABA in sma, desensitized state | electron microscopy | A, B, C, D, E | NAG, ABU | — |
| 6PLY | CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, open state | electron microscopy | A, B, C, D, E | NAG, ABU | 20 (best 0.83) |
| 6PLY | Cryoem structure of zebra fish alpha-1 glycine receptor bound with GABA in sma, open state | electron microscopy | A, B, C, D, E | NAG, ABU | — |
| 6PLZ | CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, closed state | electron microscopy | A, B, C, D, E | NAG, ABU | 20 (best 0.85) |
| 6PLZ | Cryoem structure of zebra fish alpha-1 glycine receptor bound with GABA in sma, closed state | electron microscopy | A, B, C, D, E | NAG, ABU | — |
| 6PM0 | Cryoem structure of zebra fish alpha-1 glycine receptor bound with taurine in sma, super-open state | electron microscopy | A, B, C, D, E | NAG, TAU | — |
| 6PM1 | Cryoem structure of zebra fish alpha-1 glycine receptor bound with taurine in sma, desensitized… | electron microscopy | A, B, C, D, E | NAG, TAU | — |
| 6PM2 | CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, open state | electron microscopy | A, B, C, D, E | NAG, TAU | — |
| 6PM2 | Cryoem structure of zebra fish alpha-1 glycine receptor bound with taurine in sma, open state | electron microscopy | A, B, C, D, E | NAG, TAU | — |
| 6PM3 | CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, closed state | electron microscopy | A, B, C, D, E | NAG, TAU | 19 (best 0.82) |
| 6PM3 | Cryoem structure of zebra fish alpha-1 glycine receptor bound with taurine in sma, closed state | electron microscopy | A, B, C, D, E | NAG, TAU | — |
| 6PM4 | CryoEM structure of zebra fish alpha-1 glycine receptor bound with Glycine in SMA, super-open state | electron microscopy | A, B, C, D, E | NAG, GLY | 20 (best 0.78) |
| 6PM4 | Cryoem structure of zebra fish alpha-1 glycine receptor bound with glycine in sma, super-open state | electron microscopy | A, B, C, D, E | NAG | — |
| 6PM5 | Cryoem structure of zebra fish alpha-1 glycine receptor bound with glycine in sma, desensitized… | electron microscopy | A, B, C, D, E | NAG | — |
| 6PM6 | CryoEM structure of zebra fish alpha-1 glycine receptor bound with Glycine in SMA, open state | electron microscopy | A, D, B, C, E | NAG, GLY | 20 (best 0.83) |
| 6PM6 | Cryoem structure of zebra fish alpha-1 glycine receptor bound with glycine in sma, open state | electron microscopy | A, D, B, C, E | NAG | — |
| 6PXD | Cryoem structure of zebra fish alpha-1 glycine receptor, apo state | electron microscopy | E, A, B, C, D | NAG | — |
| 6UBS | Full length glycine receptor reconstituted in lipid nanodisc in APO/RESTING conformation | electron microscopy | A, B, C, D, E | NAG, PX4, PIO | — |
| 6UBT | Full length glycine receptor reconstituted in lipid nanodisc in gly- bound desensitized conformation | electron microscopy | A, B, C, D, E | NAG | — |
| 6UD3 | Full length Glycine receptor reconstituted in lipid nanodisc in Gly/PTX-bound open/blocked… | electron microscopy | A, C, E, D, B | NAG, GLY, RI5 | 20 (best 0.80) |
| 6UD3 | Full length glycine receptor reconstituted in lipid nanodisc in GLY/PTX-bound OPEN/BLOCKED… | electron microscopy | A, C, E, D, B | NAG, RI5 | — |
| 6VM0 | Full length Glycine receptor reconstituted in lipid nanodisc in Gly/IVM-conformation (State-1) | electron microscopy | A, E, C, B, D | NAG, PIO, IVM | — |
| 6VM0 | Full length glycine receptor reconstituted in lipid nanodisc in GLY/IVM-conformation (state-1) | electron microscopy | A, E, C, B, D | NAG, PIO, GLY, IVM | 20 (best 0.80) |
| 6VM2 | Full length Glycine receptor reconstituted in lipid nanodisc in Gly/IVM-conformation (State-2) | electron microscopy | A, E, C, B, D | NAG, PIO, GLY, IVM | 20 (best 0.80) |
| 6VM2 | Full length glycine receptor reconstituted in lipid nanodisc in GLY/IVM-conformation (state-2) | electron microscopy | A, E, C, B, D | NAG, PIO, IVM | — |
| 6VM3 | Full length Glycine receptor reconstituted in lipid nanodisc in Gly/IVM-conformation (State-3) | electron microscopy | A, E, C, B, D | NAG, GLY, IVM | 20 (best 0.81) |
| 6VM3 | Full length glycine receptor reconstituted in lipid nanodisc in GLY/IVM-conformation (state-3) | electron microscopy | A, E, C, B, D | NAG, IVM | — |
| 7M6M | Full length alpha1 Glycine receptor in presence of 32uM Tetrahydrocannabinol | electron microscopy | A, B, C, E, D | NAG, TCI | 14 (best 0.85) |
| 7M6M | Full length ALPHA1 glycine receptor in presence of 32UM tetrahydrocannabinol | electron microscopy | A, B, C, E, D | NAG, TCI | — |
| 7M6N | Full length alpha1 Glycine receptor in presence of 0.1mM Glycine | electron microscopy | A, D, E, B, C | GLY, NAG | 20 (best 0.80) |
| 7M6N | Full length ALPHA1 glycine receptor in presence of 0.1MM glycine | electron microscopy | A, D, E, B, C | NAG | — |
| 7M6O | Full length alpha1 Glycine receptor in presence of 0.1mM Glycine and 32uM Tetrahydrocannabinol | electron microscopy | A, B, C, D, E | NAG, TCI | — |
| 7M6O | Full length ALPHA1 glycine receptor in presence of 0.1MM glycine and 32UM tetrahydrocannabinol | electron microscopy | A, B, C, D, E | NAG, TCI | — |
| 7M6P | Full length alpha1 Glycine receptor in presence of 1mM Glycine | electron microscopy | A, B, C, D, E | NAG, GLY | 20 (best 0.85) |
| 7M6P | Full length ALPHA1 glycine receptor in presence of 1MM glycine | electron microscopy | A, B, C, D, E | NAG | — |
| 7M6Q | Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 1 | electron microscopy | A, B, C, D, E | GLY, NAG, TCI | 20 (best 0.79) |
| 7M6Q | Full length ALPHA1 glycine receptor in presence of 1MM glycine and 32UM tetrahydrocannabinol state 1 | electron microscopy | A, B, C, D, E | NAG, TCI | — |
| 7M6R | Full length ALPHA1 glycine receptor in presence of 1MM glycine and 32UM tetrahydrocannabinol state 2 | electron microscopy | A, B, C, D, E | NAG | — |
| 7M6S | Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 3 | electron microscopy | A, B, C, D, E | NAG, GLY | 20 (best 0.82) |
| 7M6S | Full length ALPHA1 glycine receptor in presence of 1MM glycine and 32UM tetrahydrocannabinol state 3 | electron microscopy | A, B, C, D, E | NAG | — |
| 7TU9 | Alpha1/BetaB Heteromeric Glycine Receptor in Strychnine-Bound State | electron microscopy | A, D, C, B | NAG, PIO, PX4, SY9 | 17 (best 0.84) |
| 7TVI | Alpha1/BetaB Heteromeric Glycine Receptor in Glycine-Bound State | electron microscopy | A, D, C, B | GLY, NAG | 20 (best 0.80) |
| 7U2M | A novel compound mimics the structural and functional effects of the full agonist glycine on… | electron microscopy | A, B, C, D, E | NAG, L2L | 20 (best 0.80) |
| 8FE1 | Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State | electron microscopy | A, D, C, B | GLY, NAG, IVM, PX4, PLM, D10 | 20 (best 0.82) |
1 record more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 60 records
- ABU · Gamma-amino-butanoic acid · in 16 records
- GLY · Glycine · in 13 records
- TAU · 2-aminoethanesulfonic acid · in 9 records
- UNL · Unknown ligand · in 9 records
- IVM · (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar, 20BS)-6'-[(2S)-butan-2-yl]-20,20B-dihydroxy-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17A, 20,20A,20B-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside · in 7 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 6 records
- TCI · (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol · in 6 records
- PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine · in 3 records
- RI5 · (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione · in 2 records
- D10 · Decane · in 1 record
- L2L · aminomethanesulfonic acid · in 1 record
- PLM · Palmitic acid · in 1 record
- SY9 · Strychnine · in 1 record
Experiment against prediction
- 7U2M chain B against the predicted model O93430: TM-score 0.99, RMSD 0.68 Å
- 7U2M chain A against the predicted model O93430: TM-score 0.99, RMSD 0.68 Å
- 7U2M chain C against the predicted model O93430: TM-score 0.99, RMSD 0.68 Å
- 7U2M chain E against the predicted model O93430: TM-score 0.99, RMSD 0.68 Å
- 7U2M chain D against the predicted model O93430: TM-score 0.99, RMSD 0.68 Å
- 6PLR chain A against the predicted model O93430: TM-score 0.99, RMSD 0.84 Å
- 6PLR chain E against the predicted model O93430: TM-score 0.99, RMSD 0.84 Å
- 6PLR chain C against the predicted model O93430: TM-score 0.99, RMSD 0.84 Å
- 6PLR chain B against the predicted model O93430: TM-score 0.99, RMSD 0.84 Å
- 6PLR chain D against the predicted model O93430: TM-score 0.99, RMSD 0.84 Å
Elsewhere
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