Structure of tim-3 in complex with N-(4-(8-chloro-2-mehtyl-5-oxo-5,6- dihydro-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-9-yl)-3-methylphenyl) methanesulfonamdide (compound 35)

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 40% strand (DSSP).

Ligands and binding sites

• YQD · N-{4-[(4s,10ap)-8-chloro-2-methyl-5-oxo-5,6-dihydro[1, 2,4]triazolo[1,5-c]quinazolin-9-yl]-3-methylphenyl}methanesulfonamide · ligand · chains A
• CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

• 7M3Z · Structure of TIM-3 in complex with N-(4-(8-chloro-2-mehtyl-5-oxo-5,6-dihydro-[1,2,4]triazo… · the same entry in another collection · chain A against A, TM-score 1.00
• Q8TDQ0 · AlphaFold monomer V2.0 prediction for hepatitis a virus cellular receptor 2 (Q8TDQ0) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8TDQ0
• Elsewhere: RCSB PDB 7M3Z · PDBe 7M3Z · UniProt Q8TDQ0