UniProt Q8TDQ0
Hepatitis A virus cellular receptor 2 (Q8TDQ0)
Hepatitis A virus cellular receptor 2 (UniProt Q8TDQ0): 17 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8TDQ0
- Protein
- Hepatitis A virus cellular receptor 2
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 28 · 5 records with a druggable one
Structures
18 records of Q8TDQ0 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5F71 | Human T-cell immunoglobulin and mucin domain protein 3 (hTIM-3) | x-ray diffraction | A, B | NA | 3 (best 0.59) |
| 5F71 | Human T-cell immunoglobulin and mucin domain protein 3 (htim-3) | x-ray diffraction | A, B | — | — |
| 6DHB | Crystal structure of the human TIM-3 with bound Calcium | x-ray diffraction | A | CA, BEZ | — |
| 6DHB | Crystal structure of the human tim-3 with bound calcium | x-ray diffraction | A | CA, BEZ | — |
| 6TXZ | Fab part of M6903 in complex with human TIM3 | x-ray diffraction | A, B, C, D | — | 12 (best 0.81) |
| 6TXZ | Fab part of M6903 in complex with human TIM3 | x-ray diffraction | A, B, C, D | — | — |
| 7KQL | Anti-Tim3 antibody Fab complex | x-ray diffraction | T | — | 3 (best 0.45) |
| 7KQL | Anti-TIM3 antibody Fab complex | x-ray diffraction | T | — | — |
| 7M3Y | Structure of TIM-3 in complex with 8-chloro-2-methyl-9-(3-mehtylpyridin-4-yl)-[1,2,4]triazolo[1,5-c]… | x-ray diffraction | B | YQ7, CA | — |
| 7M3Y | Structure of tim-3 in complex with 8-chloro-2-methyl-9-(3… | x-ray diffraction | B | YQ7, CA | — |
| 7M3Z | Structure of TIM-3 in complex with N-(4-(8-chloro-2-mehtyl-5-oxo-5,6-dihydro-[1,2,4]triazolo[1,5-c]q… | x-ray diffraction | A | YQD, CA | — |
| 7M3Z | Structure of tim-3 in complex with N-(4-(8-chloro-2-mehtyl-5-oxo-5,6… | x-ray diffraction | A | YQD, CA | — |
| 7M41 | Structure of TIM-3 in complex with N-(4-(8-chloro-2-methyl-5-oxo-5,6-dihydro-[1,2,4]traizolo[1,5-c]q… | x-ray diffraction | A, B | YQG, CA | 4 (best 0.51) |
| 7M41 | Structure of tim-3 in complex with N-(4-(8-chloro-2-methyl-5-oxo-5,6… | x-ray diffraction | A, B | YQG, CA | — |
| 8HGJ | Toxascaris leonina galectin (Tl-gal) and Human T-cell immunoglobulin mucin-3 (Tim3) complex | electron microscopy | B | — | — |
| 8TBB | F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3 | x-ray diffraction | D | NAG | 1 (best 0.54) |
| 8TFT | Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3 | x-ray diffraction | F, G | NAG | 4 (best 0.74) |
| Q8TDQ0 | AlphaFold monomer V2.0 prediction for hepatitis a virus cellular receptor 2 (Q8TDQ0) | predicted | A | — | 1 (best 0.34) |
Ligands
- CA · Calcium ion · in 8 records
- BEZ · Benzoic acid · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- YQ7 · (4r,10ap)-8-chloro-2-methyl-9-(3-methylpyridin-4-yl)[1, 2,4]triazolo[1,5-c]quinazolin-5(6H)-one · in 2 records
- YQD · N-{4-[(4s,10ap)-8-chloro-2-methyl-5-oxo-5,6-dihydro[1, 2,4]triazolo[1,5-c]quinazolin-9-yl]-3-methylphenyl}methanesulfonamide · in 2 records
- YQG · N-{4-[(4s,10ap)-8-chloro-2-methyl-5-oxo-5,6-dihydro[1, 2,4]triazolo[1,5-c]quinazolin-9-yl]-3-methylphenyl}-1H-imidazole-2-sulfonamide · in 2 records
- NA · Sodium ion · in 1 record
Experiment against prediction
- 8TBB chain D against the predicted model Q8TDQ0: TM-score 0.97, RMSD 0.70 Å
- 6TXZ chain A against the predicted model Q8TDQ0: TM-score 0.96, RMSD 0.87 Å
- 6TXZ chain A against the predicted model Q8TDQ0: TM-score 0.96, RMSD 0.87 Å
- 7M3Z chain A against the predicted model Q8TDQ0: TM-score 0.95, RMSD 1.44 Å
- 7M3Z chain A against the predicted model Q8TDQ0: TM-score 0.95, RMSD 1.44 Å
- 6DHB chain A against the predicted model Q8TDQ0: TM-score 0.95, RMSD 0.87 Å
- 6DHB chain A against the predicted model Q8TDQ0: TM-score 0.95, RMSD 0.87 Å
- 8TFT chain F against the predicted model Q8TDQ0: TM-score 0.95, RMSD 1.18 Å
- 7M3Y chain B against the predicted model Q8TDQ0: TM-score 0.95, RMSD 1.45 Å
- 7M3Y chain B against the predicted model Q8TDQ0: TM-score 0.95, RMSD 1.45 Å
Elsewhere
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