Research workbench
Crystal structure of the second bromodomain (BD2) of human BRD3 bound to bromosporine
Analyse Crystal structure of the second bromodomain (BD2) of human BRD3 bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LB4
- Type
- protein
- Length
- 216 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain-containing protein 3
- UniProt
- Q15059
- Ligands
- BMF
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bromodomain-containing protein 3 | protein | 108 | 70% helix, 0% strand | Q15059 |
Ligands and binding sites
- BMF · Bromosporine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 635 | 0.66 | 0.76 | 53 | empty |
| 2 | 135 | 0.51 | 0.80 | 22 | BMF |
| 3 | 119 | 0.50 | 0.80 | 20 | BMF |
Interfaces
1 interface between chains.
- A–B · 258 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7LB4 · Crystal structure of the second bromodomain (BD2) of human BRD3 bound to bromosporine · the same entry in another collection · chain A against A, TM-score 1.00
- Q15059 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 3 (Q15059) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15059
- Elsewhere: RCSB PDB 7LB4 · PDBe 7LB4 · UniProt Q15059
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