UniProt Q15059
Bromodomain-containing protein 3 (Q15059)
Bromodomain-containing protein 3 (UniProt Q15059): 46 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15059
- Protein
- Bromodomain-containing protein 3
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 25 · 2 records with a druggable one
Structures
47 records of Q15059 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2E7N | Solution structure of the second Bromodomain from human Bromodomain-containing protein 3 | solution nmr | A | — | — |
| 2E7N | Solution structure of the second bromodomain from human bromodomain- containing protein 3 | solution nmr | A | — | — |
| 2NXB | Crystal structure of human Bromodomain containing protein 3 (BRD3) | x-ray diffraction | A, B | — | — |
| 2NXB | Crystal structure of human bromodomain containing protein 3 (BRD3) | x-ray diffraction | A, B | — | — |
| 2OO1 | Crystal structure of the Bromo domain 2 of human Bromodomain containing protein 3 (BRD3) | x-ray diffraction | A, B, C, D | — | — |
| 2OO1 | Crystal structure of the bromo domain 2 of human bromodomain containing protein 3 (BRD3) | x-ray diffraction | A, B, C, D | — | — |
| 2YW5 | Solution structure of the bromodomain from human bromodomain containing protein 3 | solution nmr | A | — | — |
| 2YW5 | Solution structure of the bromodomain from human bromodomain containing protein 3 | solution nmr | A | — | — |
| 3S91 | Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1 | x-ray diffraction | A | — | — |
| 3S91 | Crystal structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1 | x-ray diffraction | A | — | — |
| 3S92 | Crystal Structure of the second bromodomain of human BRD3 in complex with the inhibitor JQ1 | x-ray diffraction | A | — | — |
| 3S92 | Crystal structure of the second bromodomain of human BRD3 in complex with the inhibitor JQ1 | x-ray diffraction | A | — | — |
| 5A7C | Crystal structure of the second bromodomain of human BRD3 in complex with compound | x-ray diffraction | A, B, C, D | — | — |
| 5A7C | Crystal structure of the second bromodomain of human BRD3 in complex with compound | x-ray diffraction | A, B, C, D | — | — |
| 5HFR | Crystal structure of the second bromodomain H395R mutant of human BRD3 | x-ray diffraction | A, B, C, D | NO3 | — |
| 5HFR | Crystal structure of the second bromodomain H395R mutant of human BRD3 | x-ray diffraction | A, B, C, D | — | — |
| 5HJC | BRD3 second bromodomain in complex with histone H3 acetylation at K18 | x-ray diffraction | A | — | — |
| 6BGG | Solution NMR structures of the BRD3 et domain in complex with a CHD4 peptide | solution nmr | B | — | — |
| 6BGH | Solution NMR structure of Brd3 ET domain bound to Brg1 peptide | solution nmr | A | — | — |
| 6BGH | Solution NMR structure of BRD3 et domain bound to BRG1 peptide | solution nmr | A | — | — |
| 6I41 | Co-crystal structure of human spop math domain (wild-type) and human BRD3 fragment | x-ray diffraction | B | — | — |
| 6I5P | Co-crystal structure of human spop math domain (E47K) and human BRD3 fragment | x-ray diffraction | B, D, F, H | — | — |
| 6I68 | Co-crystal structure of human spop math domain (M117V) and human BRD3 fragment | x-ray diffraction | B, D, F, H | — | — |
| 6I7A | Co-crystal structure of human spop math domain (D140N) and human BRD3 fragment | x-ray diffraction | B, D, F, H | — | — |
| 6QJU | Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with… | x-ray diffraction | A, B | SCN, J58, NA | — |
| 6U4A | BRD3-BD1 in complex with the cyclic peptide 3.1_3 | x-ray diffraction | A, B | ACE, SO4 | — |
| 6ULP | BRD3-BD2 in complex with the cyclic peptide 3.2_3 | x-ray diffraction | A, B | ACE | — |
| 7JMY | Solution NMR structure of human BRD3 et domain | solution nmr | A | — | — |
| 7JQ8 | Solution NMR structure of human Brd3 ET domain | solution nmr | A | — | 1 (best 0.34) |
| 7JQ8 | Solution NMR structure of human BRD3 et domain | solution nmr | A | — | — |
| 7JYN | Solution NMR structure of human BRD3 et complexed with NSD3(148-184) peptide | solution nmr | A | — | — |
| 7JYZ | Solution NMR structure and dynamics of human BRD3 et in complex with mlv in ctd | solution nmr | B | — | — |
| 7L72 | Crystal structure of the second bromodomain (BD2) of human BRD3 bound to RO3280 | x-ray diffraction | A | 79C | — |
| 7L9L | Crystal structure of the second bromodomain (BD2) of human BRD3 bound to BI2536 | x-ray diffraction | A | R78 | — |
| 7LAY | Crystal structure of the first bromodomain (BD1) of human BRD3 bound to SG3-179 | x-ray diffraction | A, B | 5W2 | — |
| 7LAZ | Crystal structure of the first bromodomain (BD1) of human BRD3 bound to ERK5-in-1 | x-ray diffraction | A, B | VYJ | — |
| 7LB4 | Crystal structure of the second bromodomain (BD2) of human BRD3 bound to bromosporine | x-ray diffraction | A, B | BMF | — |
| 7LBT | Crystal structure of the second bromodomain (BD2) of human BRD3 bound to ERK5-in-1 | x-ray diffraction | A, B, C, D | VYJ | — |
| 7R8R | Physachenolide C with Bromodomain (BRD3-BD1) | x-ray diffraction | A | 8L6 | — |
| 7RJK | Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with hnrnpk | x-ray diffraction | A, B | SO4 | — |
| 7RJL | Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with shmt | x-ray diffraction | A, B | ALY | — |
| 7RJM | Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with ILF3 | x-ray diffraction | A, B | — | — |
| 7RJN | Crystal structure of human bromodomain containing protein 3 (BRD3) in complex with BCLTF1 | x-ray diffraction | A, B | — | — |
| 7S3P | BD2 domain of human BRD3 bound to Physachenolide C | x-ray diffraction | K, A, B, C, D, E, F, G, H, I, J | 8L6, CL | 20 (best 0.77) |
| 7TO7 | BRD3-BD1 in complex with RaPID linear peptide 1xAcK.4XE (monoAcK.4xE) | x-ray diffraction | A, B, D, E | — | — |
| 7UG5 | Second bromodomain of BRD3 liganded with BMS-536924 | x-ray diffraction | A, B, C, D | N6I | 4 (best 0.80) |
| Q15059 | AlphaFold monomer V2.0 prediction for bromodomain-containing protein 3 (Q15059) | predicted | A | — | — |
Ligands
- 8L6 · Physachenolide C · in 2 records
- ACE · Acetyl group · in 2 records
- SO4 · Sulfate ion · in 2 records
- VYJ · 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one · in 2 records
- 5W2 · 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{N}-(1-methylpiperidin-4-yl)benzamide · in 1 record
- 79C · 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl) amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide · in 1 record
- ALY · N(6)-acetyllysine · in 1 record
- BMF · Bromosporine · in 1 record
- CL · Chloride ion · in 1 record
- J58 · 3-bromanyl-2~{H}-indazol-5-amine · in 1 record
- N6I · (3M)-4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-3-[4-methyl-6-(morpholin-4-yl)-1H-benzimidazol-2-yl]pyridin-2(1H)-one · in 1 record
- NA · Sodium ion · in 1 record
- NO3 · Nitrate ion · in 1 record
- R78 · 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide · in 1 record
- SCN · Thiocyanate ion · in 1 record
Experiment against prediction
- 7S3P chain A against the predicted model Q15059: TM-score 0.99, RMSD 0.33 Å
- 7S3P chain G against the predicted model Q15059: TM-score 0.99, RMSD 0.33 Å
- 7S3P chain D against the predicted model Q15059: TM-score 0.99, RMSD 0.34 Å
- 7S3P chain I against the predicted model Q15059: TM-score 0.99, RMSD 0.34 Å
- 7S3P chain B against the predicted model Q15059: TM-score 0.99, RMSD 0.34 Å
- 7S3P chain J against the predicted model Q15059: TM-score 0.99, RMSD 0.34 Å
- 7S3P chain H against the predicted model Q15059: TM-score 0.99, RMSD 0.35 Å
- 7S3P chain C against the predicted model Q15059: TM-score 0.99, RMSD 0.36 Å
- 7S3P chain K against the predicted model Q15059: TM-score 0.99, RMSD 0.36 Å
- 7S3P chain E against the predicted model Q15059: TM-score 0.99, RMSD 0.36 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.