Research workbench
CTF3C with ULP2-kim
Analyse CTF3C with ULP2-kim in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7L7Q
- Type
- protein
- Length
- 687 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inner kinetochore subunit MCM16; Inner kinetochore subunit CTF3; Inner kinetochore…
- UniProt
- Q12262, Q12748, P47167
- Pockets
- 10 · best druggability 0.65
Structure
electron microscopy · 3 distinct chains · 64% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Inner kinetochore subunit MCM16 | protein | 133 | 80% helix, 0% strand | Q12262 |
| I | Inner kinetochore subunit CTF3 | protein | 427 | 56% helix, 0% strand | Q12748 |
| K | Inner kinetochore subunit MCM22 | protein | 127 | 73% helix, 0% strand | P47167 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 169 | 0.65 | 0.85 | 27 | empty |
| 2 | 201 | 0.62 | 0.83 | 29 | empty |
| 3 | 125 | 0.55 | 0.82 | 27 | empty |
| 4 | 74 | 0.49 | 0.84 | 16 | empty |
| 5 | 71 | 0.41 | 0.79 | 21 | empty |
Interfaces
3 interfaces between chains.
- H–K · 3652 Ų buried · 27 hydrogen bonds · protein-protein
- H–I · 2905 Ų buried · 27 hydrogen bonds · protein-protein
- I–K · 1768 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 7L7Q · Ctf3c with Ulp2-KIM · the same entry in another collection · chain H against H, TM-score 1.00
- Q12748 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit CTF3 (Q12748) · a predicted model of the same protein · chain I against A, TM-score 0.95
- Q12262 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit MCM16 (Q12262) · a predicted model of the same protein · chain H against A, TM-score 0.94
- P47167 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit MCM22 (P47167) · a predicted model of the same protein · chain K against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12262
- Every structure of UniProt Q12748
- Every structure of UniProt P47167
- Elsewhere: RCSB PDB 7L7Q · PDBe 7L7Q · UniProt Q12262 · UniProt Q12748 · UniProt P47167
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.