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DNA polymerase mu, 8-OXODGTP:CT reaction state ternary complex, 50 mm MG2+ (90MIN)

Analyse DNA polymerase mu, 8-OXODGTP:CT reaction state ternary complex, 50 mm MG2+… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7KTE
Type
protein + DNA
Length
346 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
Q9NP87
Ligands
PPV, 8DG, MG, NA, CL

Structure

x-ray diffraction · 4 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein328—Q9NP87
T—dna9——
P—dna5——
D—dna4——

Ligands and binding sites

  • PPV · Pyrophosphate · ligand · chains A, P
  • 8DG · 8-oxo-2'-deoxyguanosine-5'-triphosphate · ligand · chains A, T, P
  • MG · Magnesium ion · metal · 2 copies · chains A, P
  • NA · Sodium ion · metal · chains A, P
  • CL · Chloride ion · ion · chains A
  • EDO · 1,2-ethanediol · additive · 7 copies · chains A, T, P
  • EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A
  • DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A
  • GOL · Glycerol · additive · chains A, T

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7KTE · DNA Polymerase Mu, 8-oxodGTP:Ct Reaction State Ternary Complex, 50 mM Mg2+ (90min) · the same entry in another collection · chain A against A, TM-score 1.00
  • Q9NP87 · AlphaFold monomer V2.0 prediction for DNA-directed DNA/RNA polymerase mu (Q9NP87) · a predicted model of the same protein · chain A against A, TM-score 0.99

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