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Crystal structure of importin alpha 3 in complex with human LSD1 nls

Analyse Crystal structure of importin alpha 3 in complex with human LSD1 nls in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7JJL
Type: protein
Length: 418 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-3; Lysine-specific histone demethylase 1A
EC: 1.14.99.66
UniProt: O00629, O60341
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-3	protein	412	73% helix, 0% strand	O00629
B	Lysine-specific histone demethylase 1A (EC 1.14.99.66)	protein	6	0% helix, 0% strand	O60341

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.38	0.79	15	empty

Interfaces

1 interface between chains.

A–B · 627 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

7JJL · Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS · the same entry in another collection · chain A against A, TM-score 1.00
O00629 · AlphaFold monomer V2.0 prediction for importin subunit alpha-3 (O00629) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00629
Every structure of UniProt O60341
Elsewhere: RCSB PDB 7JJL · PDBe 7JJL · UniProt O00629 · UniProt O60341

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