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Structure of ATTPC1 with 1 mm CA2+

Analyse Structure of ATTPC1 with 1 mm CA2+ in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7FHK
Type: protein
Length: 1,350 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Two pore calcium channel protein 1,GFP; ATTPC1-cter
UniProt: Q94KI8
Ligands: CA
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 2 distinct chains · 76% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Two pore calcium channel protein 1,GFP	protein	663	76% helix, 1% strand	Q94KI8
B, D	ATTPC1-cter	protein	12	83% helix, 0% strand	—

Ligands and binding sites

CA · Calcium ion · metal · 4 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	853	0.87	0.89	47	empty
2	1014	0.79	0.80	72	empty
3	598	0.79	0.84	44	empty
4	494	0.78	0.85	39	empty
5	671	0.73	0.79	60	empty

Interfaces

3 interfaces between chains.

A–C · 4077 Å² buried · 11 hydrogen bonds · protein-protein
C–D · 273 Å² buried · 1 hydrogen bond · protein-protein
A–B · 264 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7FHK · Structure of AtTPC1 with 1 mM Ca2+ · the same entry in another collection · chain A against A, TM-score 1.00
Q94KI8 · AlphaFold monomer V2.0 prediction for two pore calcium channel protein 1 (Q94KI8) · a predicted model of the same protein · chain C against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q94KI8
Elsewhere: RCSB PDB 7FHK · PDBe 7FHK · UniProt Q94KI8

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