Research workbench
Crystal structure of tcptp catalytic domain
Analyse Crystal structure of tcptp catalytic domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7F5N
- Type
- protein
- Length
- 874 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 2
- EC
- 3.1.3.48
- UniProt
- P17706
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 37% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) | protein | 296 | 36% helix, 22% strand | P17706 |
| B | Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) | protein | 287 | 37% helix, 22% strand | P17706 |
| C | Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) | protein | 291 | 37% helix, 22% strand | P17706 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 678 | 0.72 | 0.79 | 51 | empty |
| 2 | 100 | 0.44 | 0.79 | 25 | empty |
| 3 | 112 | 0.43 | 0.78 | 17 | empty |
| 4 | 61 | 0.41 | 0.81 | 17 | empty |
| 5 | 50 | 0.26 | 0.74 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–C · 633 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 23 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17706
- Elsewhere: RCSB PDB 7F5N · PDBe 7F5N · UniProt P17706
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.