UniProt P17706
Tyrosine-protein phosphatase non-receptor type 2 (P17706)
Tyrosine-protein phosphatase non-receptor type 2 (UniProt P17706), EC 3.1.3.48: 7 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 8 pockets. Binding sites, druggability and experiment against…
- UniProt
- P17706
- Protein
- Tyrosine-protein phosphatase non-receptor type 2
- EC
- 3.1.3.48
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 8 · 3 records with a druggable one
Structures
8 records of P17706 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1L8K | T Cell Protein-Tyrosine Phosphatase Structure | x-ray diffraction | A | — | — |
| 1L8K | T cell protein-tyrosine phosphatase structure | x-ray diffraction | A | — | — |
| 6ZZ4 | Crystal structure of the PTPN2 C216G mutant | x-ray diffraction | A, B | PO4 | 5 (best 0.78) |
| 6ZZ4 | Crystal structure of the PTPN2 C216G mutant | x-ray diffraction | A, B | PO4 | — |
| 7F5N | Crystal structure of tcptp catalytic domain | x-ray diffraction | A, B, C | — | — |
| 7F5O | Crystal structure of PTPN2 catalytic domain | x-ray diffraction | A, B, C | IOD | — |
| 8U0H | Crystal structure of PTPN2 with a PROTAC | x-ray diffraction | A, B | UB0, NA | 1 (best 0.71) |
| P17706 | AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 2 (P17706) | predicted | A | — | 2 (best 0.68) |
Ligands
- PO4 · Phosphate ion · in 2 records
- IOD · Iodide ion · in 1 record
- NA · Sodium ion · in 1 record
- UB0 · (5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[2-(4-{3-[(3R)-2,6-dioxopiperidin-3-yl]-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl}piperidin-1-yl)acetamido]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid · in 1 record
Experiment against prediction
- 8U0H chain B against the predicted model P17706: TM-score 1.00, RMSD 0.39 Å
- 7F5O chain B against the predicted model P17706: TM-score 0.99, RMSD 0.46 Å
- 7F5N chain C against the predicted model P17706: TM-score 0.99, RMSD 0.48 Å
- 7F5N chain B against the predicted model P17706: TM-score 0.99, RMSD 0.52 Å
- 7F5O chain C against the predicted model P17706: TM-score 0.99, RMSD 0.53 Å
- 6ZZ4 chain B against the predicted model P17706: TM-score 0.99, RMSD 0.61 Å
- 6ZZ4 chain B against the predicted model P17706: TM-score 0.99, RMSD 0.61 Å
- 8U0H chain A against the predicted model P17706: TM-score 0.99, RMSD 0.57 Å
- 6ZZ4 chain A against the predicted model P17706: TM-score 0.99, RMSD 0.65 Å
- 6ZZ4 chain A against the predicted model P17706: TM-score 0.99, RMSD 0.65 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.