MolNFT v1 · #319646 · protein
AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 2 (P17706)
P17706: “AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 2 (P17706)”. 2 pockets (best druggability 0.68). MolNFT v1 #319646 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P17706
- Type
- protein
- Length
- 415 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x4BE1cF35Da14aE929555183fb31BD9CE38270CaE
- Molecule
- Tyrosine-protein phosphatase non-receptor type 2
- UniProt
- P17706
- Pockets
- 2 · best druggability 0.68
Structure
1 distinct chain · 45% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 2 | protein | 415 | 45% helix, 16% strand | P17706 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 838 | 0.68 | 0.75 | 72 | empty |
| 2 | 216 | 0.54 | 0.78 | 34 | empty |
Compared structures
- 7F5N · Crystal structure of tcptp catalytic domain · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7F5O · Crystal structure of PTPN2 catalytic domain · an experimental structure of the same protein · chain A against A, TM-score 0.69
- 6ZZ4 · Crystal structure of the PTPN2 C216G mutant · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 6ZZ4 · Crystal structure of the PTPN2 C216G mutant · an experimental structure of the same protein · chain A against A, TM-score 0.67
- 1L8K · T Cell Protein-Tyrosine Phosphatase Structure · an experimental structure of the same protein · chain A against A, TM-score 0.64
- 1L8K · T cell protein-tyrosine phosphatase structure · an experimental structure of the same protein · chain A against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17706
- Elsewhere: UniProt P17706 · AlphaFold DB P17706
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