Research workbench
Cryo-EM structure of the type 1 bradykinin receptor in complex with the des-ARG10-kallidin and an gq protein
Analyse Cryo-EM structure of the type 1 bradykinin receptor in complex with the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EIB
- Type
- protein
- Length
- 928 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- B1 bradykinin receptor; Lys-arg-pro-pro-gly-phe-ser-pro-phe; G subunit Q (GI1-gq…
- UniProt
- P46663, P54311, P63212
- Pockets
- 8 · best druggability 0.82
Structure
electron microscopy · 5 distinct chains · 44% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | B1 bradykinin receptor | protein | 295 | 79% helix, 4% strand | P46663 |
| D | Lys-arg-pro-pro-gly-phe-ser-pro-phe | protein | 9 | 0% helix, 0% strand | — |
| B | G subunit Q (GI1-gq chimeric) | protein | 235 | 51% helix, 18% strand | — |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 9% helix, 47% strand | P54311 |
| E | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 51 | 51% helix, 0% strand | P63212 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 631 | 0.82 | 0.87 | 62 | empty |
| 2 | 974 | 0.75 | 0.78 | 71 | empty |
| 3 | 157 | 0.47 | 0.77 | 27 | empty |
| 4 | 188 | 0.46 | 0.75 | 27 | empty |
| 5 | 119 | 0.44 | 0.77 | 26 | empty |
Interfaces
5 interfaces between chains.
- C–E · 2059 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 1523 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 1331 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 930 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 97 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7EIB · Cryo-EM structure of the type 1 bradykinin receptor in complex with the… · the same entry in another collection · chain E against E, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.99
- P46663 · AlphaFold monomer V2.0 prediction for B1 bradykinin receptor (P46663) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain E against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46663
- Every structure of UniProt P54311
- Every structure of UniProt P63212
- Elsewhere: RCSB PDB 7EIB · PDBe 7EIB · UniProt P46663 · UniProt P54311 · UniProt P63212
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.