Research workbench
Human 46QHUNTINGTIN-HAP40 complex structure
Analyse Human 46QHUNTINGTIN-HAP40 complex structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DXJ
- Type
- protein
- Length
- 2,621 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Huntingtin; 40-kda huntingtin-associated protein
- UniProt
- P42858, P23610
- Pockets
- 20 · best druggability 0.90
Structure
electron microscopy · 2 distinct chains · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Huntingtin | protein | 2353 | 63% helix, 0% strand | P42858 |
| B | 40-kda huntingtin-associated protein | protein | 268 | 78% helix, 0% strand | P23610 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 843 | 0.90 | 0.93 | 141 | empty |
| 2 | 289 | 0.75 | 0.88 | 31 | empty |
| 3 | 71 | 0.74 | 0.97 | 18 | empty |
| 4 | 224 | 0.74 | 0.89 | 32 | empty |
| 5 | 761 | 0.73 | 0.79 | 57 | empty |
Interfaces
1 interface between chains.
- A–B · 5137 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42858
- Every structure of UniProt P23610
- Elsewhere: RCSB PDB 7DXJ · PDBe 7DXJ · UniProt P42858 · UniProt P23610
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.