UniProt P42858
Huntingtin (P42858)
Huntingtin (UniProt P42858): 45 experimental structures on GenesisL1, 1 ligand bound, 129 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P42858
- Protein
- Huntingtin
- Experimental structures
- 45
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 129 · 7 records with a druggable one
Structures
45 records of P42858 in the MolNFT archive: 45 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LD0 | Solution structure of the N-terminal domain of huntingtin (htt17) in 50 % TFE | solution nmr | A | — | — |
| 2LD0 | Solution structure of the N-terminal domain of huntingtin (HTT17) in 50 % tfe | solution nmr | A | — | — |
| 2LD2 | Solution structure of the N-terminal domain of huntingtin (htt17) in presence of DPC micelles | solution nmr | A | — | — |
| 2LD2 | Solution structure of the N-terminal domain of huntingtin (HTT17) in presence of dpc micelles | solution nmr | A | — | — |
| 3IO4 | Huntingtin amino-terminal region with 17 Gln residues - Crystal C90 | x-ray diffraction | A, B, C | — | — |
| 3IO4 | Huntingtin amino-terminal region with 17 gln residues - crystal C90 | x-ray diffraction | A, B, C | — | — |
| 3IO6 | Huntingtin amino-terminal region with 17 Gln residues - crystal C92-a | x-ray diffraction | A, C, B | — | — |
| 3IO6 | Huntingtin amino-terminal region with 17 gln residues - crystal C92-a | x-ray diffraction | A, C, B | — | — |
| 3IOR | Huntingtin amino-terminal region with 17 Gln residues - crystal C95 | x-ray diffraction | A, B, C | — | — |
| 3IOR | Huntingtin amino-terminal region with 17 gln residues - crystal C95 | x-ray diffraction | A, B, C | — | — |
| 3IOT | Huntingtin amino-terminal region with 17 Gln residues - crystal C92-b | x-ray diffraction | A, B, C | — | — |
| 3IOT | Huntingtin amino-terminal region with 17 gln residues - crystal C92-B | x-ray diffraction | A, B, C | — | — |
| 3IOU | Huntingtin amino-terminal region with 17 Gln residues - crystal C94 | x-ray diffraction | A, B, C | — | — |
| 3IOU | Huntingtin amino-terminal region with 17 gln residues - crystal C94 | x-ray diffraction | A, B, C | — | — |
| 3IOV | Huntingtin amino-terminal region with 17 Gln residues - crystal C99 | x-ray diffraction | A, B, C | — | — |
| 3IOV | Huntingtin amino-terminal region with 17 gln residues - crystal C99 | x-ray diffraction | A, B, C | — | — |
| 3IOW | Huntingtin amino-terminal region with 17 Gln residues - crystal C99-Hg | x-ray diffraction | A, B, C | — | — |
| 3IOW | Huntingtin amino-terminal region with 17 gln residues - crystal C99-hg | x-ray diffraction | A, B, C | — | — |
| 3LRH | Structure of anti-huntingtin VL domain in complex with huntingtin peptide | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 3LRH | Structure of anti-huntingtin vl domain in complex with huntingtin peptide | x-ray diffraction | B, D, F, H, J, L, N, P | — | — |
| 4FE8 | Crystal Structure of Htt36Q3H-EX1-X1-C1(Alpha) | x-ray diffraction | A, B, C | — | — |
| 4FE8 | Crystal structure of HTT36Q3H-EX1-X1-C1(ALPHA) | x-ray diffraction | A, B, C | — | — |
| 4FEB | Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta) | x-ray diffraction | A, B, C | — | — |
| 4FEB | Crystal structure of HTT36Q3H-EX1-X1-C2(BETA) | x-ray diffraction | A, B, C | — | — |
| 4FEC | Crystal Structure of Htt36Q3H | x-ray diffraction | A, B, C | — | — |
| 4FEC | Crystal structure of HTT36Q3H | x-ray diffraction | A, B, C | — | — |
| 4FED | Crystal Structure of Htt36Q3H | x-ray diffraction | A, B, C | — | — |
| 4FED | Crystal structure of HTT36Q3H | x-ray diffraction | A, B, C | — | — |
| 4RAV | Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin | x-ray diffraction | E, F | — | — |
| 4RAV | Crystal structure of SCFVC4 in complex with the first 17 aa of huntingtin | x-ray diffraction | E, F | — | — |
| 6EZ8 | Human huntingtin-HAP40 complex structure | electron microscopy | A | — | — |
| 6N8C | Structure of the Huntingtin tetramer/dimer mixture determined by paramagnetic NMR | solution nmr | A, B, C, D | — | — |
| 6N8C | Structure of the huntingtin TETRAMER/DIMER mixture determined by paramagnetic NMR | solution nmr | A, B, C, D | — | — |
| 6RMH | The Rigid-body refined model of the normal Huntingtin. | electron microscopy | A | — | 20 (best 0.82) |
| 6RMH | The rigid-body refined model of the normal huntingtin. | electron microscopy | A | — | — |
| 6X9O | High resolution cryoEM structure of huntingtin in complex with HAP40 | electron microscopy | A | — | 19 (best 0.87) |
| 6X9O | High resolution cryoem structure of huntingtin in complex with HAP40 | electron microscopy | A | — | — |
| 6YEJ | Cryo-EM structure of the Full-length disease type human Huntingtin | electron microscopy | A | — | 20 (best 0.80) |
| 6YEJ | Cryo-EM structure of the full-length disease type human huntingtin | electron microscopy | A | — | — |
| 7DXJ | Human 46QHuntingtin-HAP40 complex structure | electron microscopy | A | — | 20 (best 0.90) |
| 7DXJ | Human 46QHUNTINGTIN-HAP40 complex structure | electron microscopy | A | — | — |
| 7DXK | Human 128QHuntingtin-HAP40 complex structure | electron microscopy | A | — | 20 (best 0.89) |
| 7DXK | Human 128QHUNTINGTIN-HAP40 complex structure | electron microscopy | A | — | — |
| 8R2O | Huntingtin-Q17, 1-66, N-MBP fusion | x-ray diffraction | A, B | GLC | 10 (best 0.75) |
| 8W15 | HTT in complex with HAP40 in the apo state. | electron microscopy | A | — | 20 (best 0.83) |
Ligands
- GLC · alpha-D-glucopyranose · in 1 record
Experiment against prediction
- 3IOR chain A against the predicted model P0AEX9: TM-score 0.77, RMSD 3.44 Å
- 3IOU chain B against the predicted model P0AEX9: TM-score 0.77, RMSD 3.49 Å
- 3IOT chain A against the predicted model P0AEX9: TM-score 0.77, RMSD 3.53 Å
- 3IOW chain C against the predicted model P0AEX9: TM-score 0.77, RMSD 3.46 Å
- 3IOW chain B against the predicted model P0AEX9: TM-score 0.75, RMSD 3.44 Å
- 3IOU chain A against the predicted model P0AEX9: TM-score 0.75, RMSD 3.45 Å
- 3IOW chain A against the predicted model P0AEX9: TM-score 0.73, RMSD 3.46 Å
- 3IOR chain C against the predicted model P0AEX9: TM-score 0.75, RMSD 3.50 Å
- 3IOV chain C against the predicted model P0AEX9: TM-score 0.75, RMSD 3.49 Å
- 3IOU chain C against the predicted model P0AEX9: TM-score 0.75, RMSD 3.49 Å
Elsewhere
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