UniProt P23610
40-kDa huntingtin-associated protein (P23610)
40-kDa huntingtin-associated protein (UniProt P23610): 11 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 68 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P23610
- Protein
- 40-kDa huntingtin-associated protein
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 68 · 7 records with a druggable one
Structures
12 records of P23610 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EZ8 | Human Huntingtin-HAP40 complex structure | electron microscopy | B | — | 9 (best 0.90) |
| 6EZ8 | Human huntingtin-HAP40 complex structure | electron microscopy | B | — | — |
| 6X9O | High resolution cryoEM structure of huntingtin in complex with HAP40 | electron microscopy | B | — | 12 (best 0.87) |
| 6X9O | High resolution cryoem structure of huntingtin in complex with HAP40 | electron microscopy | B | — | — |
| 7DXJ | Human 46QHuntingtin-HAP40 complex structure | electron microscopy | B | — | 10 (best 0.90) |
| 7DXJ | Human 46QHUNTINGTIN-HAP40 complex structure | electron microscopy | B | — | — |
| 7DXK | Human 128QHuntingtin-HAP40 complex structure | electron microscopy | B | — | 8 (best 0.89) |
| 7DXK | Human 128QHUNTINGTIN-HAP40 complex structure | electron microscopy | B | — | — |
| 8SAH | Huntingtin C-HEAT domain in complex with HAP40 | electron microscopy | B | — | 8 (best 0.89) |
| 8VLX | HTT in complex with HAP40 and a small molecule. | electron microscopy | B | A1ACS | 11 (best 0.90) |
| 8W15 | HTT in complex with HAP40 in the apo state. | electron microscopy | B | — | 10 (best 0.83) |
| P23610 | AlphaFold monomer V2.0 prediction for 40-kda huntingtin-associated protein (P23610) | predicted | A | — | — |
Ligands
- A1ACS · N-[(1S,2R)-2-benzylcyclopentyl]-N'-{1-[(1S)-1-(pyridin-4-yl)ethyl]piperidin-4-yl}urea · in 1 record
Experiment against prediction
- 7DXJ chain B against the predicted model P23610: TM-score 0.96, RMSD 1.33 Å
- 7DXJ chain B against the predicted model P23610: TM-score 0.96, RMSD 1.33 Å
- 7DXK chain B against the predicted model P23610: TM-score 0.96, RMSD 1.28 Å
- 7DXK chain B against the predicted model P23610: TM-score 0.96, RMSD 1.28 Å
- 6EZ8 chain B against the predicted model P23610: TM-score 0.95, RMSD 1.43 Å
- 6EZ8 chain B against the predicted model P23610: TM-score 0.95, RMSD 1.43 Å
- 8W15 chain B against the predicted model P23610: TM-score 0.95, RMSD 1.43 Å
- 8VLX chain B against the predicted model P23610: TM-score 0.95, RMSD 1.46 Å
- 6X9O chain B against the predicted model P23610: TM-score 0.94, RMSD 1.53 Å
- 6X9O chain B against the predicted model P23610: TM-score 0.94, RMSD 1.53 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.