Research workbench
Structure of a human NHE1-CHP1 complex under pH 6.5
Analyse Structure of a human NHE1-CHP1 complex under pH 6.5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DSV
- Type
- protein
- Length
- 1,296 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SODIUM/HYDROGEN exchanger 1; Calcineurin B homologous protein 1
- UniProt
- P19634, Q99653
- Ligands
- LBN
- Pockets
- 17 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 65% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SODIUM/HYDROGEN exchanger 1 | protein | 463 | 70% helix, 0% strand | P19634 |
| D, C | Calcineurin B homologous protein 1 | protein | 185 | 52% helix, 1% strand | Q99653 |
Ligands and binding sites
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · ligand · 16 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1084 | 0.83 | 0.84 | 62 | LBN |
| 2 | 1137 | 0.81 | 0.83 | 130 | empty |
| 3 | 1106 | 0.81 | 0.82 | 124 | empty |
| 4 | 451 | 0.70 | 0.81 | 40 | empty |
| 5 | 479 | 0.70 | 0.80 | 40 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3407 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 1031 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 1012 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7DSV · Structure of a human NHE1-CHP1 complex under pH 6.5 · the same entry in another collection · chain A against A, TM-score 1.00
- P19634 · AlphaFold monomer V2.0 prediction for SODIUM/HYDROGEN exchanger 1 (P19634) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q99653 · AlphaFold monomer V2.0 prediction for calcineurin B homologous protein 1 (Q99653) · a predicted model of the same protein · chain D against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19634
- Every structure of UniProt Q99653
- Elsewhere: RCSB PDB 7DSV · PDBe 7DSV · UniProt P19634 · UniProt Q99653
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