UniProt Q99653
Calcineurin B homologous protein 1 (Q99653)
Calcineurin B homologous protein 1 (UniProt Q99653): 7 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99653
- Protein
- Calcineurin B homologous protein 1
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 15 · 2 records with a druggable one
Structures
8 records of Q99653 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2E30 | Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential… | solution nmr | A | — | — |
| 2E30 | Solution structure of the cytoplasmic region of NA+/H+ exchanger 1 complexed with essential… | solution nmr | A | — | — |
| 7DSV | Structure of a human NHE1-CHP1 complex under pH 6.5 | electron microscopy | D, C | — | 4 (best 0.81) |
| 7DSV | Structure of a human NHE1-CHP1 complex under pH 6.5 | electron microscopy | D, C | — | — |
| 7DSX | Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide | electron microscopy | D, C | — | 11 (best 0.84) |
| 7DSX | Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide | electron microscopy | D, C | — | — |
| 7X2U | Structure of a human NHE3-CHP1 complex in the autoinhibited state | electron microscopy | C, D | 85R | — |
| Q99653 | AlphaFold monomer V2.0 prediction for calcineurin B homologous protein 1 (Q99653) | predicted | A | — | — |
Ligands
- 85R · [(2~{R})-2-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{S}, 5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl) cyclohexyl]oxy-phosphoryl]oxy-propyl] hexadecanoate · in 1 record
Experiment against prediction
- 7X2U chain D against the predicted model Q99653: TM-score 0.94, RMSD 1.37 Å
- 7X2U chain C against the predicted model Q99653: TM-score 0.94, RMSD 1.37 Å
- 7DSV chain D against the predicted model Q99653: TM-score 0.93, RMSD 1.52 Å
- 7DSV chain D against the predicted model Q99653: TM-score 0.93, RMSD 1.52 Å
- 7DSV chain C against the predicted model Q99653: TM-score 0.93, RMSD 1.52 Å
- 7DSV chain C against the predicted model Q99653: TM-score 0.93, RMSD 1.52 Å
- 7DSX chain C against the predicted model Q99653: TM-score 0.93, RMSD 1.53 Å
- 7DSX chain D against the predicted model Q99653: TM-score 0.93, RMSD 1.53 Å
- 7DSX chain C against the predicted model Q99653: TM-score 0.93, RMSD 1.53 Å
- 7DSX chain D against the predicted model Q99653: TM-score 0.93, RMSD 1.53 Å
Elsewhere
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