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Crystal structure of SNX27 ferm domain in complex with a dlf motif

Analyse Crystal structure of SNX27 ferm domain in complex with a dlf motif in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7CT1
Type: protein
Length: 263 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fusion protein sorting nexin-27 and dlf motif
UniProt: Q96L92
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fusion protein sorting nexin-27 and dlf motif	protein	263	33% helix, 28% strand	Q96L92

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	277	0.68	0.83	47	empty
2	86	0.41	0.78	13	empty
3	64	0.30	0.75	17	empty
4	55	0.28	0.75	14	empty

Compared structures

7CT1 · Crystal structure of Snx27 FERM domain in complex with a DLF motif · the same entry in another collection · chain A against A, TM-score 1.00
Q96L92 · AlphaFold monomer V2.0 prediction for sorting nexin-27 (Q96L92) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96L92
Elsewhere: RCSB PDB 7CT1 · PDBe 7CT1 · UniProt Q96L92

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