Research workbench
Crystal structure of the thorarchaeota 2DGEL3/RABBIT actin complex
Analyse Crystal structure of the thorarchaeota 2DGEL3/RABBIT actin complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7C2H
- Type
- protein
- Length
- 553 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle; 2DGEL3
- UniProt
- P68135, A0A135VDL7
- Ligands
- ATP, CA
- Pockets
- 5 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Actin, alpha skeletal muscle | protein | 356 | 47% helix, 21% strand | P68135 |
| G | 2DGEL3 | protein | 197 | 25% helix, 34% strand | A0A135VDL7 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- CA · Calcium ion · metal · 6 copies · chains A, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 910 | 0.84 | 0.86 | 115 | CA, ATP |
| 2 | 258 | 0.59 | 0.78 | 33 | empty |
| 3 | 167 | 0.50 | 0.77 | 25 | empty |
| 4 | 66 | 0.32 | 0.75 | 18 | empty |
| 5 | 60 | 0.28 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–G · 2143 Ų buried · 29 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (methylation).
Compared structures
- 7C2H · Crystal Structure of the Thorarchaeota 2DGel3/rabbit actin complex · the same entry in another collection · chain A against A, TM-score 1.00
- P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68135
- Every structure of UniProt A0A135VDL7
- Elsewhere: RCSB PDB 7C2H · PDBe 7C2H · UniProt P68135 · UniProt A0A135VDL7
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