Research workbench
Mavc-UBE2N-ub complex
Analyse Mavc-UBE2N-ub complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BXG
- Type
- protein
- Length
- 601 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mavc; Ubiquitin-conjugating enzyme E2 N; Polyubiquitin-C
- EC
- 2.3.2.23
- UniProt
- Q5ZTL4, P61088, P0CG48
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mavc | protein | 377 | 50% helix, 15% strand | Q5ZTL4 |
| B | Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) | protein | 150 | 33% helix, 17% strand | P61088 |
| D | Polyubiquitin-C | protein | 74 | 26% helix, 31% strand | P0CG48 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1010 | 0.78 | 0.80 | 82 | empty |
| 2 | 1010 | 0.74 | 0.77 | 95 | empty |
| 3 | 251 | 0.58 | 0.78 | 38 | empty |
| 4 | 55 | 0.37 | 0.80 | 13 | empty |
| 5 | 57 | 0.33 | 0.77 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1267 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 1242 Ų buried · 24 hydrogen bonds · protein-protein
- B–D · 202 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 isopeptide (isopeptide).
Compared structures
- 7BXG · MavC-UBE2N-Ub complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZTL4
- Every structure of UniProt P61088
- Every structure of UniProt P0CG48
- Elsewhere: RCSB PDB 7BXG · PDBe 7BXG · UniProt Q5ZTL4 · UniProt P61088 · UniProt P0CG48
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