UniProt P61088
Ubiquitin-conjugating enzyme E2 N (P61088)
Ubiquitin-conjugating enzyme E2 N (UniProt P61088), EC 2.3.2.23, 6.3.2.19: 81 experimental structures and 1 predicted model on GenesisL1, 94 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P61088
- Protein
- Ubiquitin-conjugating enzyme E2 N
- EC
- 2.3.2.23, 6.3.2.19
- Experimental structures
- 81
- Predicted models
- 1
- Pockets
- 94 · 13 records with a druggable one
Structures
82 records of P61088 in the MolNFT archive: 81 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1J7D | Crystal Structure of hMms2-hUbc13 | x-ray diffraction | B | — | 2 (best 0.47) |
| 1J7D | Crystal structure of HMMS2-HUBC13 | x-ray diffraction | B | — | — |
| 2C2V | Crystal structure of the CHIP-UBC13-UEV1a complex | x-ray diffraction | B, E, H, K | — | — |
| 2C2V | Crystal structure of the chip-UBC13-UEV1A complex | x-ray diffraction | B, E, H, K | — | — |
| 3HCT | Crystal structure of TRAF6 in complex with Ubc13 in the P1 space group | x-ray diffraction | B | — | — |
| 3HCT | Crystal structure of TRAF6 in complex with UBC13 in the P1 space group | x-ray diffraction | B | — | — |
| 3HCU | Crystal structure of TRAF6 in complex with Ubc13 in the C2 space group | x-ray diffraction | B, D | — | — |
| 3HCU | Crystal structure of TRAF6 in complex with UBC13 in the C2 space group | x-ray diffraction | B, D | — | — |
| 3VON | Crystalstructure of the ubiquitin protease | x-ray diffraction | C, E, G, J, L, N, Q, S, U, X, Z, b, e, g, i, l, n, p | — | — |
| 3VON | Crystalstructure of the ubiquitin protease | x-ray diffraction | C, E, G, J, L, N, Q, S, U, X, Z, b, e, g, i, l, n, p | — | — |
| 3W31 | Structual basis for the recognition of Ubc13 by the Shigella flexneri effector OspI | x-ray diffraction | B | — | — |
| 3W31 | Structual basis for the recognition of UBC13 by the shigella flexneri effector ospi | x-ray diffraction | B | — | — |
| 4DHI | Structure of C. elegans OTUB1 bound to human UBC13 | x-ray diffraction | D | — | — |
| 4DHI | Structure of C. elegans OTUB1 bound to human UBC13 | x-ray diffraction | D | — | — |
| 4DHJ | The structure of a ceOTUB1 ubiquitin aldehyde UBC13~Ub complex | x-ray diffraction | C, K, G, N | — | — |
| 4DHJ | The structure of a CEOTUB1 ubiquitin aldehyde UBC13~UB complex | x-ray diffraction | C, K, G, N | — | — |
| 4DHZ | The structure of h/ceOTUB1-ubiquitin aldehyde-UBC13~Ub | x-ray diffraction | F | — | — |
| 4DHZ | The structure of H/CEOTUB1-ubiquitin aldehyde-UBC13~UB | x-ray diffraction | F | — | — |
| 4IP3 | Complex structure of OspI and Ubc13 | x-ray diffraction | B | — | — |
| 4IP3 | Complex structure of ospi and UBC13 | x-ray diffraction | B | — | — |
| 4NR3 | Crystal Structure of a human Mms2/Ubc13 L121G mutant | x-ray diffraction | B | — | — |
| 4NR3 | Crystal structure of a human MMS2/UBC13 L121G mutant | x-ray diffraction | B | — | — |
| 4NRG | Crystal Structure of a human Mms2/Ubc13 D118G mutant | x-ray diffraction | B | — | — |
| 4NRG | Crystal structure of a human MMS2/UBC13 D118G mutant | x-ray diffraction | B | — | — |
| 4NRI | Crystal Structure of a human Mms2/Ubc13 A122G mutant | x-ray diffraction | B | — | — |
| 4NRI | Crystal structure of a human MMS2/UBC13 A122G mutant | x-ray diffraction | B | — | — |
| 4ONL | Crystal structure of human Mms2/Ubc13_D81N, R85S, A122V, N123P | x-ray diffraction | B | — | — |
| 4ONL | Crystal structure of human MMS2/UBC13_D81N, R85S, A122V, N123P | x-ray diffraction | B | — | — |
| 4ONM | Crystal structure of human Mms2/Ubc13 - NSC697923 | x-ray diffraction | B | — | — |
| 4ONM | Crystal structure of human MMS2/UBC13 - NSC697923 | x-ray diffraction | B | — | — |
| 4ONN | Crystal structure of human Mms2/Ubc13 - BAY 11-7082 | x-ray diffraction | B | — | — |
| 4ONN | Crystal structure of human MMS2/UBC13 - bay 11-7082 | x-ray diffraction | B | — | — |
| 4ORH | Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer | x-ray diffraction | B, F, J | — | — |
| 4ORH | Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer | x-ray diffraction | B, F, J | — | — |
| 4TKP | Complex of Ubc13 with the RING domain of the TRIM5alpha retroviral restriction factor | x-ray diffraction | A | — | — |
| 4TKP | Complex of UBC13 with the ring domain of the TRIM5ALPHA retroviral restriction factor | x-ray diffraction | A | — | — |
| 4WHV | E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and… | x-ray diffraction | B, E, H, K | — | — |
| 4WHV | E3 ubiquitin-protein ligase RNF8 in complex with ubiquitin-conjugating enzyme E2 N and… | x-ray diffraction | B, E, H, K | — | — |
| 5AIT | A complex of of RNF4-RING domain, UbeV2, Ubc13-Ub (isopeptide crosslink) | x-ray diffraction | B, E | — | — |
| 5AIT | A complex of of RNF4-ring domain, UBEV2, UBC13-ub (isopeptide crosslink) | x-ray diffraction | B, E | — | — |
| 5AIU | A complex of RNF4-RING domain, Ubc13-Ub (isopeptide crosslink) | x-ray diffraction | B, E | — | — |
| 5AIU | A complex of RNF4-ring domain, UBC13-ub (isopeptide crosslink) | x-ray diffraction | B, E | — | — |
| 5EYA | TRIM25 RING domain in complex with Ubc13-Ub conjugate | x-ray diffraction | A, B | — | — |
| 5EYA | TRIM25 ring domain in complex with UBC13-ub conjugate | x-ray diffraction | A, B | — | — |
| 5H7S | Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1… | x-ray diffraction | A, C | — | — |
| 5H7S | Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1… | x-ray diffraction | A, C | — | — |
| 5VNZ | Structure of a TRAF6-Ubc13~Ub complex | x-ray diffraction | B, E | — | 11 (best 0.48) |
| 5VNZ | Structure of a TRAF6-UBC13~UB complex | x-ray diffraction | B, E | — | — |
| 5VO0 | Structure of a TRAF6-Ubc13~Ub complex | x-ray diffraction | B, E | — | 7 (best 0.56) |
| 5VO0 | Structure of a TRAF6-UBC13~UB complex | x-ray diffraction | B, E | — | — |
| 5YWR | Crystal Structure of RING E3 ligase ZNRF1 in complex with Ube2N (Ubc13) | x-ray diffraction | A | — | 2 (best 0.45) |
| 5YWR | Crystal structure of ring E3 ligase ZNRF1 in complex with UBE2N (UBC13) | x-ray diffraction | A | — | — |
| 6D6I | Ube2V1 in complex with ubiquitin variant Ubv.V1.1 and Ube2N/Ubc13 | x-ray diffraction | B, E | — | 6 (best 0.67) |
| 6D6I | UBE2V1 in complex with ubiquitin variant UBV.V1.1 and UBE2N/UBC13 | x-ray diffraction | B, E | — | — |
| 6JKY | Crystal structure of MvcA-UBE2N-Ub complex from Legionella pneumophila | x-ray diffraction | B, E | — | 7 (best 0.83) |
| 6JKY | Crystal structure of mvca-UBE2N-ub complex from legionella pneumophila | x-ray diffraction | B, E | — | — |
| 6KFP | Crystal structure of MavC ternary complex | x-ray diffraction | B | — | — |
| 6KFP | Crystal structure of mavc ternary complex | x-ray diffraction | B | — | — |
| 6KG6 | Crystal structure of MavC/UBE2N-Ub complex | x-ray diffraction | G | — | — |
| 6KG6 | Crystal structure of MAVC/UBE2N-ub complex | x-ray diffraction | G | — | — |
22 records more on the page itself.
Experiment against prediction
- 5AIU chain B against the predicted model P61088: TM-score 0.99, RMSD 0.47 Å
- 5AIU chain B against the predicted model P61088: TM-score 0.99, RMSD 0.47 Å
- 6S53 chain C against the predicted model P61088: TM-score 0.99, RMSD 0.47 Å
- 6S53 chain C against the predicted model P61088: TM-score 0.99, RMSD 0.47 Å
- 5EYA chain A against the predicted model P61088: TM-score 0.99, RMSD 0.50 Å
- 5EYA chain A against the predicted model P61088: TM-score 0.99, RMSD 0.50 Å
- 5VO0 chain E against the predicted model P61088: TM-score 0.99, RMSD 0.52 Å
- 5VO0 chain E against the predicted model P61088: TM-score 0.99, RMSD 0.52 Å
- 6S53 chain E against the predicted model P61088: TM-score 0.99, RMSD 0.53 Å
- 6S53 chain E against the predicted model P61088: TM-score 0.99, RMSD 0.53 Å
Elsewhere
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