Research workbench
Cryo-EM structure for the ectodomain of the full-length human insulin receptor in complex with 1 insulin.
Analyse Cryo-EM structure for the ectodomain of the full-length human insulin receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BW7
- Type
- protein
- Length
- 1,091 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin fusion
- EC
- 2.7.10.1
- UniProt
- P06213, P01308
- Pockets
- 18 · best druggability 0.83
Structure
electron microscopy · 3 distinct chains · 10% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor (EC 2.7.10.1) | protein | 647 | 9% helix, 20% strand | P06213 |
| C | Insulin receptor (EC 2.7.10.1) | protein | 396 | 11% helix, 16% strand | P06213 |
| D | Insulin fusion | protein | 48 | 23% helix, 0% strand | P01308 |
Pockets
18 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1187 | 0.83 | 0.84 | 116 | empty |
| 2 | 318 | 0.80 | 0.90 | 49 | empty |
| 3 | 89 | 0.76 | 0.96 | 23 | empty |
| 4 | 52 | 0.69 | 0.97 | 26 | empty |
| 5 | 674 | 0.66 | 0.75 | 82 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1638 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 896 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 368 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 17 disulfide (disulfide).
Compared structures
- 7BW7 · Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex… · the same entry in another collection · chain A against A, TM-score 1.00
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain C against A, TM-score 0.64
- P01308 · AlphaFold monomer V2.0 prediction for insulin (P01308) · a predicted model of the same protein · chain D against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7BW7 · PDBe 7BW7 · UniProt P06213 · UniProt P01308
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