Research workbench
Structure of the integrator cleavage module with extended INTS4 and rigid body docked INTS9/11 ctd
Analyse Structure of the integrator cleavage module with extended INTS4 and rigid body… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BFQ
- Type
- protein
- Length
- 1,626 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrator complex subunit 9; Integrator complex subunit 4; Integrator complex subunit…
- EC
- 3.1.27.-
- UniProt
- Q9NV88, Q96HW7, Q5TA45
- Pockets
- 18 · best druggability 0.87
Structure
electron microscopy · 4 distinct chains · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrator complex subunit 9 | protein | 603 | 28% helix, 24% strand | Q9NV88 |
| C | Integrator complex subunit 4 | protein | 298 | 68% helix, 1% strand | Q96HW7 |
| B | Integrator complex subunit 11 (EC 3.1.27.-) | protein | 590 | 32% helix, 20% strand | Q5TA45 |
| U | Unknown | protein | 135 | 72% helix, 0% strand | — |
Pockets
18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 900 | 0.87 | 0.89 | 102 | empty |
| 2 | 495 | 0.79 | 0.87 | 76 | empty |
| 3 | 521 | 0.79 | 0.86 | 70 | empty |
| 4 | 797 | 0.73 | 0.78 | 102 | empty |
| 5 | 274 | 0.72 | 0.86 | 48 | empty |
Interfaces
5 interfaces between chains.
- A–B · 3082 Ų buried · 48 hydrogen bonds · protein-protein
- A–C · 1219 Ų buried · 12 hydrogen bonds · protein-protein
- C–B · 648 Ų buried · 1 hydrogen bond · protein-protein
- C–U · 325 Ų buried · 3 hydrogen bonds · protein-protein
- B–U · 49 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7BFQ · Structure of the Integrator cleavage module with extended INTS4 and rigid body docked… · the same entry in another collection · chain A against A, TM-score 1.00
- Q96HW7 · AlphaFold monomer V2.0 prediction for integrator complex subunit 4 (Q96HW7) · a predicted model of the same protein · chain C against A, TM-score 0.94
- Q9NV88 · AlphaFold monomer V2.0 prediction for integrator complex subunit 9 (Q9NV88) · a predicted model of the same protein · chain A against A, TM-score 0.89
- Q5TA45 · AlphaFold monomer V2.0 prediction for integrator complex subunit 11 (Q5TA45) · a predicted model of the same protein · chain B against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NV88
- Every structure of UniProt Q96HW7
- Every structure of UniProt Q5TA45
- Elsewhere: RCSB PDB 7BFQ · PDBe 7BFQ · UniProt Q9NV88 · UniProt Q96HW7 · UniProt Q5TA45
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