Research workbench
TRPC4 in lmng detergent
Analyse TRPC4 in lmng detergent in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7B0J
- Type
- protein
- Length
- 2,728 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily C member 4A
- UniProt
- U3N7D8
- Ligands
- LPP, CA
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 65% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transient receptor potential cation channel subfamily C member 4A | protein | 682 | 65% helix, 1% strand | U3N7D8 |
Ligands and binding sites
- LPP · 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate · ligand · 4 copies · chains A, D, B, C
- CA · Calcium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1075 | 0.85 | 0.86 | 71 | empty |
| 2 | 995 | 0.83 | 0.83 | 73 | empty |
| 3 | 1103 | 0.83 | 0.84 | 86 | empty |
| 4 | 1097 | 0.82 | 0.83 | 87 | empty |
| 5 | 980 | 0.82 | 0.83 | 69 | empty |
Interfaces
6 interfaces between chains.
- C–D · 5268 Ų buried · 47 hydrogen bonds · protein-protein
- A–B · 5268 Ų buried · 47 hydrogen bonds · protein-protein
- A–D · 5265 Ų buried · 47 hydrogen bonds · protein-protein
- B–C · 5263 Ų buried · 47 hydrogen bonds · protein-protein
- B–D · 84 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7B0J · TRPC4 in LMNG detergent · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt U3N7D8
- Elsewhere: RCSB PDB 7B0J · PDBe 7B0J · UniProt U3N7D8
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