Research workbench
Crystal structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Analyse Crystal structure of an engineered helicase domain construct for human bloom… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7AUC
- Type
- protein
- Length
- 493 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bloom syndrome PROTEIN,BLOOM syndrome protein
- EC
- 3.6.4.12
- UniProt
- P54132
- Ligands
- ADP, MG, CA, ZN
- Pockets
- 4 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bloom syndrome PROTEIN,BLOOM syndrome protein (EC 3.6.4.12) | protein | 493 | 50% helix, 13% strand | P54132 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
- CA · Calcium ion · metal · 2 copies · chains A
- ZN · Zinc ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 6 copies · chains A
- ACT · Acetate ion · additive · 4 copies · chains A
- PG4 · Tetraethylene glycol · additive · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 664 | 0.83 | 0.87 | 76 | EDO, GOL, ADP, MG, CA |
| 2 | 228 | 0.53 | 0.77 | 27 | empty |
| 3 | 208 | 0.51 | 0.76 | 30 | empty |
| 4 | 65 | 0.32 | 0.76 | 18 | ACT |
Compared structures
- 7AUC · Crystal structure of an engineered helicase domain construct for human Bloom syndrome… · the same entry in another collection · chain A against A, TM-score 1.00
- P54132 · AlphaFold monomer V2.0 prediction for bloom syndrome protein (P54132) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54132
- Elsewhere: RCSB PDB 7AUC · PDBe 7AUC · UniProt P54132
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