UniProt P54132
Bloom syndrome protein,Bloom syndrome protein (P54132)
Bloom syndrome protein,Bloom syndrome protein (UniProt P54132), EC 3.6.4.12: 23 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 24 pockets. Binding sites, druggability and experiment against…
- UniProt
- P54132
- Protein
- Bloom syndrome protein,Bloom syndrome protein
- EC
- 3.6.4.12
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 24 · 2 records with a druggable one
Structures
24 records of P54132 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KV2 | Solution Structure of the human BLM HRDC domain | solution nmr | A | — | — |
| 2KV2 | Solution structure of the human blm hrdc domain | solution nmr | A | — | — |
| 2MH9 | Resonance assignment of RQC domain of human Bloom syndrome protein | solution nmr | A | — | — |
| 2MH9 | Resonance assignment of rqc domain of human bloom syndrome protein | solution nmr | A | — | — |
| 2RRD | Structure of HRDC domain from human Bloom syndrome protein, BLM | solution nmr | A | — | — |
| 2RRD | Structure of hrdc domain from human bloom syndrome protein, blm | solution nmr | A | — | — |
| 3WE2 | Structure of BLM RQC domain bound to a phosphate ion | x-ray diffraction | A, B | — | — |
| 3WE2 | Structure of blm rqc domain bound to a phosphate ion | x-ray diffraction | A, B | — | — |
| 3WE3 | Structure of BLM RQC domain bound to an arsenate ion | x-ray diffraction | A, B | — | — |
| 3WE3 | Structure of blm rqc domain bound to an arsenate ion | x-ray diffraction | A, B | — | — |
| 4CDG | Crystal structure of the Bloom's syndrome helicase BLM in complex with Nanobody | x-ray diffraction | A, B | — | — |
| 4CDG | Crystal structure of the BLOOM'S syndrome helicase blm in complex with nanobody | x-ray diffraction | A, B | — | — |
| 4CGZ | Crystal structure of the Bloom's syndrome helicase BLM in complex with DNA | x-ray diffraction | A | — | — |
| 4CGZ | Crystal structure of the BLOOM'S syndrome helicase blm in complex with DNA | x-ray diffraction | A | — | — |
| 4O3M | Ternary complex of Bloom's syndrome helicase | x-ray diffraction | A | — | — |
| 4O3M | Ternary complex of BLOOM'S syndrome helicase | x-ray diffraction | A | — | — |
| 5MK5 | Structures of DHBN domain of human BLM helicase | x-ray diffraction | A, B, C, D | IOD, K | — |
| 5MK5 | Structures of dhbn domain of human blm helicase | x-ray diffraction | A, B, C, D | IOD, K | — |
| 7AUC | Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) | x-ray diffraction | A | ADP, MG, ZN, CA | 4 (best 0.83) |
| 7AUC | Crystal structure of an engineered helicase domain construct for human bloom syndrome protein (blm) | x-ray diffraction | A | ADP, MG, ZN, CA | — |
| 7AUD | Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) | x-ray diffraction | A, B, C, D, E, F | ZN, ADP, RY8, MG | 20 (best 0.82) |
| 7AUD | Structure of an engineered helicase domain construct for human bloom syndrome protein (blm) | x-ray diffraction | A, B, C, D, E, F | ZN, ADP, RY8, MG | — |
| 7XV0 | Crystal structure of RPA70N-BLMp1 fusion | x-ray diffraction | B | — | — |
| P54132 | AlphaFold monomer V2.0 prediction for bloom syndrome protein (P54132) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7AUC chain A against the predicted model P54132: TM-score 0.94, RMSD 2.15 Å
- 7AUC chain A against the predicted model P54132: TM-score 0.94, RMSD 2.15 Å
- 4O3M chain A against the predicted model P54132: TM-score 0.93, RMSD 2.46 Å
- 4O3M chain A against the predicted model P54132: TM-score 0.93, RMSD 2.46 Å
- 3WE3 chain B against the predicted model P54132: TM-score 0.93, RMSD 1.27 Å
- 3WE3 chain B against the predicted model P54132: TM-score 0.93, RMSD 1.27 Å
- 4CGZ chain A against the predicted model P54132: TM-score 0.93, RMSD 2.56 Å
- 4CGZ chain A against the predicted model P54132: TM-score 0.93, RMSD 2.56 Å
- 3WE2 chain B against the predicted model P54132: TM-score 0.92, RMSD 1.43 Å
- 3WE2 chain B against the predicted model P54132: TM-score 0.92, RMSD 1.43 Å
Elsewhere
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