Research workbench
Crystal structure of HSC70 ATPase domain in complex with ADP and calcium
Analyse Crystal structure of HSC70 ATPase domain in complex with ADP and calcium in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZYJ
- Type
- protein
- Length
- 760 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock cognate 71 kda protein
- UniProt
- P11142
- Ligands
- ADP, CA
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Heat shock cognate 71 kda protein | protein | 380 | 40% helix, 29% strand | P11142 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- CA · Calcium ion · metal · 4 copies · chains A, B
- ACT · Acetate ion · additive · 2 copies · chains A, B
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 689 | 0.77 | 0.82 | 74 | ADP, CA |
| 2 | 707 | 0.77 | 0.82 | 74 | CA, ADP |
| 3 | 120 | 0.64 | 0.88 | 24 | GOL |
| 4 | 108 | 0.38 | 0.75 | 24 | empty |
| 5 | 86 | 0.35 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 484 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6ZYJ · Crystal structure of Hsc70 ATPase domain in complex with ADP and calcium · the same entry in another collection · chain A against A, TM-score 1.00
- P11142 · AlphaFold monomer V2.0 prediction for heat shock cognate 71 kda protein (P11142) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11142
- Elsewhere: RCSB PDB 6ZYJ · PDBe 6ZYJ · UniProt P11142
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