UniProt P11142
Heat shock cognate 71 kDa protein (P11142)
Heat shock cognate 71 kDa protein (UniProt P11142), EC 3.6.3.51: 66 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P11142
- Protein
- Heat shock cognate 71 kDa protein
- EC
- 3.6.3.51
- Experimental structures
- 66
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 8 · 2 records with a druggable one
Structures
67 records of P11142 in the MolNFT archive: 66 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3AGY | Crystal structure of human Hsp40 Hdj1 peptide-binding domain complexed with a C-terminal peptide of… | x-ray diffraction | C, D, F | — | — |
| 3AGY | Crystal structure of human HSP40 HDJ1 peptide-binding domain complexed with a C-terminal peptide of… | x-ray diffraction | C, D, F | — | — |
| 3AGZ | Crystal structure of human Hsp40 Hdj1 peptide-binding domain complexed with a C-terminal peptide of… | x-ray diffraction | C, D, E, F | — | — |
| 3AGZ | Crystal structure of human HSP40 HDJ1 peptide-binding domain complexed with a C-terminal peptide of… | x-ray diffraction | C, D, E, F | — | — |
| 3ESK | Structure of HOP TPR2A domain in complex with the non-cognate Hsc70 peptide ligand | x-ray diffraction | B | — | — |
| 3ESK | Structure of hop TPR2A domain in complex with the non-cognate HSC70 peptide ligand | x-ray diffraction | B | — | — |
| 3FZF | Crystal Structure of Hsc70/Bag1 in complex with ATP | x-ray diffraction | A | — | — |
| 3FZF | Crystal structure of HSC70/BAG1 in complex with ATP | x-ray diffraction | A | — | — |
| 3FZH | Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors | x-ray diffraction | A | — | — |
| 3FZH | Crystal structures of HSC70/BAG1 in complex with small molecule inhibitors | x-ray diffraction | A | — | — |
| 3FZK | Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors | x-ray diffraction | A | — | — |
| 3FZK | Crystal structures of HSC70/BAG1 in complex with small molecule inhibitors | x-ray diffraction | A | — | — |
| 3FZL | Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors | x-ray diffraction | A | — | — |
| 3FZL | Crystal structures of HSC70/BAG1 in complex with small molecule inhibitors | x-ray diffraction | A | — | — |
| 3FZM | Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors | x-ray diffraction | A | — | — |
| 3FZM | Crystal structures of HSC70/BAG1 in complex with small molecule inhibitors | x-ray diffraction | A | — | — |
| 3LDQ | Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 3LDQ | Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 3M3Z | Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 3M3Z | Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor | x-ray diffraction | A | — | — |
| 4H5N | HSC70 NBD with PO4, Na, Cl | x-ray diffraction | A, B | — | — |
| 4H5N | HSC70 nbd with PO4, na, cl | x-ray diffraction | A, B | — | — |
| 4H5R | HSC70 NBD with Na, Cl and glycerol | x-ray diffraction | A, B | — | — |
| 4H5R | HSC70 nbd with na, cl and glycerol | x-ray diffraction | A, B | — | — |
| 4H5T | HSC70 NBD with ADP and Mg | x-ray diffraction | A | — | — |
| 4H5T | HSC70 nbd with ADP and mg | x-ray diffraction | A | — | — |
| 4H5V | HSC70 NBD with Mg | x-ray diffraction | A | — | — |
| 4H5V | HSC70 nbd with mg | x-ray diffraction | A | — | — |
| 4H5W | HSC70 NBD with betaine | x-ray diffraction | A, B | — | — |
| 4H5W | HSC70 nbd with betaine | x-ray diffraction | A, B | — | — |
| 4HWI | Crystal structure of ATBAG1 in complex with HSP70 | x-ray diffraction | A | — | — |
| 4HWI | Crystal structure of ATBAG1 in complex with HSP70 | x-ray diffraction | A | — | — |
| 4KBQ | Structure of the CHIP-TPR domain in complex with the Hsc70 Lid-Tail domains | x-ray diffraction | D, C | — | — |
| 4KBQ | Structure of the chip-tpr domain in complex with the HSC70 lid-tail domains | x-ray diffraction | D, C | — | — |
| 5AQF | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQF | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQG | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C, E | — | — |
| 5AQH | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQH | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQI | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQI | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQJ | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C, E | — | — |
| 5AQK | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQK | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQL | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQL | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQM | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQM | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQN | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C, E | — | — |
| 5AQO | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C, E | — | — |
| 5AQP | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C, E | — | — |
| 5AQQ | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C, E | — | — |
| 5AQR | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C, E | — | — |
| 5AQS | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQS | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A, C | — | — |
| 5AQT | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQT | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQU | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQU | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQV | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | KC7 | 3 (best 0.73) |
7 records more on the page itself.
Ligands
- ADP · Adenosine-5'-diphosphate · in 4 records
- CA · Calcium ion · in 2 records
- MG · Magnesium ion · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- KC7 · (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 4H5T chain A against the predicted model P11142: TM-score 0.89, RMSD 2.59 Å
- 4H5T chain A against the predicted model P11142: TM-score 0.89, RMSD 2.59 Å
- 6B1N chain A against the predicted model P11142: TM-score 0.88, RMSD 2.74 Å
- 6B1N chain B against the predicted model P11142: TM-score 0.88, RMSD 2.82 Å
- 6B1M chain B against the predicted model P11142: TM-score 0.87, RMSD 2.79 Å
- 6ZYJ chain B against the predicted model P11142: TM-score 0.87, RMSD 2.79 Å
- 6ZYJ chain A against the predicted model P11142: TM-score 0.87, RMSD 2.86 Å
- 6ZYJ chain A against the predicted model P11142: TM-score 0.87, RMSD 2.86 Å
- 6B1I chain A against the predicted model P11142: TM-score 0.87, RMSD 2.80 Å
- 4H5W chain A against the predicted model P11142: TM-score 0.87, RMSD 2.80 Å
Elsewhere
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