Research workbench
Adenylosuccinate synthetase from H. pylori in complex with hda, GDP, imo, mg
Analyse Adenylosuccinate synthetase from H. pylori in complex with hda, GDP, imo, mg in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZXQ
- Type
- protein
- Length
- 410 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylosuccinate synthetase
- EC
- 6.3.4.4
- UniProt
- P56137
- Ligands
- HDA, GDP, IMO, MG
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylosuccinate synthetase (EC 6.3.4.4) | protein | 410 | 36% helix, 23% strand | P56137 |
Ligands and binding sites
- HDA · Hadacidin · ligand · chains A
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- IMO · 6-O-phosphoryl inosine monophosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 257 | 0.78 | 0.91 | 44 | HDA, IMO |
| 2 | 214 | 0.65 | 0.84 | 28 | GDP |
| 3 | 66 | 0.29 | 0.74 | 15 | empty |
Compared structures
- 6ZXQ · Adenylosuccinate Synthetase from H. pylori in complex with HDA, GDP, IMO, Mg · the same entry in another collection · chain A against A, TM-score 1.00
- P56137 · AlphaFold monomer V2.0 prediction for adenylosuccinate synthetase (P56137) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P56137
- Elsewhere: RCSB PDB 6ZXQ · PDBe 6ZXQ · UniProt P56137
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.