UniProt P56137
Adenylosuccinate synthetase (P56137)
Adenylosuccinate synthetase (UniProt P56137), EC 6.3.4.4: 5 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P56137
- Protein
- Adenylosuccinate synthetase
- EC
- 6.3.4.4
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 15 · 5 records with a druggable one
Structures
6 records of P56137 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6ZXQ | Adenylosuccinate Synthetase from H. pylori in complex with HDA, GDP, IMO, Mg | x-ray diffraction | A | HDA, GDP, IMO, MG | 3 (best 0.78) |
| 6ZXQ | Adenylosuccinate synthetase from H. pylori in complex with hda, GDP, imo, mg | x-ray diffraction | A | HDA, GDP, IMO, MG | — |
| 7PVO | Adenylosuccinate Synthetase from H. pylori in complex with IMP | x-ray diffraction | A | IMP, SO4 | 1 (best 0.78) |
| 8QWA | Adenylosuccinate Synthetase from H. pylori in complex with PLP and IMP | x-ray diffraction | A | IMP, PLP, SO4 | 2 (best 0.76) |
| 9F17 | Crystal structure of N term His-tag Adenylosuccinate synthetase from Helicobacter pylori | x-ray diffraction | A, B | CA, GDP, IMP, SO4 | 8 (best 0.79) |
| P56137 | AlphaFold monomer V2.0 prediction for adenylosuccinate synthetase (P56137) | predicted | A | — | 1 (best 0.80) |
Ligands
- GDP · Guanosine-5'-diphosphate · in 3 records
- IMP · Inosinic acid · in 3 records
- SO4 · Sulfate ion · in 3 records
- HDA · Hadacidin · in 2 records
- IMO · 6-O-phosphoryl inosine monophosphate · in 2 records
- MG · Magnesium ion · in 2 records
- CA · Calcium ion · in 1 record
- PLP · Pyridoxal-5'-phosphate · in 1 record
Experiment against prediction
- 9F17 chain A against the predicted model P56137: TM-score 0.98, RMSD 0.94 Å
- 6ZXQ chain A against the predicted model P56137: TM-score 0.98, RMSD 1.01 Å
- 6ZXQ chain A against the predicted model P56137: TM-score 0.98, RMSD 1.01 Å
- 8QWA chain A against the predicted model P56137: TM-score 0.98, RMSD 1.12 Å
- 7PVO chain A against the predicted model P56137: TM-score 0.97, RMSD 1.26 Å
Elsewhere
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