Crystal structure of the fifth bromodomain of human protein polybromo- 1 in complex with tert-butyl 4-[3-amino-6-(2-HYDROXYPHENYL)PYRIDAZIN- 4-YL]PIPERAZINE-1-carboxylate

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 2% strand (DSSP).

Ligands and binding sites

• QP8 · tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate · ligand · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Compared structures

• 6ZS4 · Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• Q86U86 · AlphaFold monomer V2.0 prediction for protein polybromo-1 (Q86U86) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q86U86
• Elsewhere: RCSB PDB 6ZS4 · PDBe 6ZS4 · UniProt Q86U86