Research workbench
Cryo-EM structure of the regulatory linker of ALC1 bound to the NUCLEOSOME'S acidic patch: nucleosome class.
Analyse Cryo-EM structure of the regulatory linker of ALC1 bound to the NUCLEOSOME'S… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ZHX
- Type
- protein + DNA
- Length
- 1,074 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3; Histone H4; Histone H2A type 1; Histone H2B 1.1; DNA (145-mer) widom 601…
- EC
- 3.6.4.12
- UniProt
- A0A310TTQ1, P62799, P06897, P02281, Q86WJ1
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 7 distinct chains · 63% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Histone H3 | protein | 98 | 67% helix, 4% strand | A0A310TTQ1 |
| B, F | Histone H4 | protein | 83 | 60% helix, 7% strand | P62799 |
| C, G | Histone H2A type 1 | protein | 110 | 55% helix, 5% strand | P06897 |
| D, H | Histone H2B 1.1 | protein | 97 | 73% helix, 4% strand | P02281 |
| I | DNA (145-mer) widom 601 sequence | dna | 145 | — | — |
| J | DNA (145-mer) widom 601 sequence | dna | 145 | — | — |
| K, L | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12) | protein | 4 | 0% helix, 0% strand | Q86WJ1 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 840 | 0.80 | 0.83 | 84 | empty |
| 2 | 599 | 0.80 | 0.86 | 72 | empty |
| 3 | 391 | 0.75 | 0.86 | 46 | empty |
| 4 | 824 | 0.74 | 0.79 | 57 | empty |
| 5 | 850 | 0.74 | 0.78 | 78 | empty |
Interfaces
42 interfaces between chains.
- I–J · 6563 Ų buried · 530 hydrogen bonds · nucleic-nucleic
- C–D · 2606 Ų buried · 25 hydrogen bonds · protein-protein
- E–F · 2594 Ų buried · 29 hydrogen bonds · protein-protein
- G–H · 2586 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2572 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 6ZHX · Cryo-EM structure of the regulatory linker of ALC1 bound to the nucleosome's acidic… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A310TTQ1
- Every structure of UniProt P62799
- Every structure of UniProt P06897
- Every structure of UniProt P02281
- Every structure of UniProt Q86WJ1
- Elsewhere: RCSB PDB 6ZHX · PDBe 6ZHX · UniProt A0A310TTQ1 · UniProt P62799 · UniProt P06897 · UniProt P02281 · UniProt Q86WJ1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.