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NMR solution structure of unbound recombinant human nerve growth factor (rhngf)

Analyse NMR solution structure of unbound recombinant human nerve growth factor (rhngf) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6YW8
Type: protein
Length: 236 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-nerve growth factor
UniProt: P01138
Pockets: 1 · best druggability 0.59

Structure

solution nmr · 1 distinct chain · 0% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta-nerve growth factor	protein	118	0% helix, 53% strand	P01138

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	375	0.59	0.76	41	empty

Interfaces

1 interface between chains.

A–B · 1948 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

6YW8 · NMR solution structure of unbound recombinant human Nerve Growth Factor (rhNGF) · the same entry in another collection · chain A against A, TM-score 1.00
P01138 · AlphaFold monomer V2.0 prediction for beta-nerve growth factor (P01138) · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01138
Elsewhere: RCSB PDB 6YW8 · PDBe 6YW8 · UniProt P01138

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