AlphaFold monomer V2.0 prediction for beta-nerve growth factor (P01138)

Structure

1 distinct chain · 17% helix, 31% strand (DSSP).

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

• 5JZ7 · NGF IN COMPLEX WITH MEDI578 scFv · an experimental structure of the same protein · chain A against B, TM-score 0.42
• 5JZ7 · Ngf in complex with MEDI578 scfv · an experimental structure of the same protein · chain A against A, TM-score 0.41
• 1WWW · Ngf in complex with domain 5 of the trka receptor · an experimental structure of the same protein · chain A against W, TM-score 0.40
• 1WWW · Ngf in complex with domain 5 of the trka receptor · an experimental structure of the same protein · chain A against W, TM-score 0.40
• 2IFG · Structure of the extracellular segment of human trka in complex with nerve growth factor · an experimental structure of the same protein · chain A against F, TM-score 0.40
• 2IFG · Structure of the extracellular segment of human TRKA in complex with nerve growth factor · an experimental structure of the same protein · chain A against F, TM-score 0.40
• 4EDW · Nerve Growth Factor in Complex with Fab from humanized version of mouse mAb 911… · an experimental structure of the same protein · chain A against V, TM-score 0.40
• 4EDW · Nerve growth factor in complex with Fab from humanized version of mouse mab 911… · an experimental structure of the same protein · chain A against V, TM-score 0.40
• 4EDX · Nerve growth factor in complex with Fab from mouse mab 911 · an experimental structure of the same protein · chain A against W, TM-score 0.40

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P01138
• Elsewhere: UniProt P01138 · AlphaFold DB P01138