Research workbench
Binary complex of 14-3-3 zeta with glucocorticoid receptor (gr) PT524 PS617 peptide
Analyse Binary complex of 14-3-3 zeta with glucocorticoid receptor (gr) PT524 PS617… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6YOS
- Type
- protein
- Length
- 461 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein ZETA/DELTA; Glucocorticoid RECEPTOR,GLUCOCORTICOID receptor
- UniProt
- P63104, P04150
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein ZETA/DELTA | protein | 224 | 83% helix, 0% strand | P63104 |
| B | 14-3-3 protein ZETA/DELTA | protein | 219 | 83% helix, 0% strand | P63104 |
| C | Glucocorticoid RECEPTOR,GLUCOCORTICOID receptor | protein | 18 | 0% helix, 0% strand | P04150 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 719 | 0.68 | 0.76 | 66 | empty |
| 2 | 187 | 0.52 | 0.78 | 30 | empty |
| 3 | 50 | 0.42 | 0.83 | 12 | empty |
| 4 | 125 | 0.40 | 0.75 | 15 | empty |
| 5 | 56 | 0.28 | 0.75 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1015 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 610 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 599 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 6YOS · Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 pS617 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P63104 · AlphaFold monomer V2.0 prediction for 14-3-3 protein ZETA/DELTA (P63104) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P04150 · AlphaFold monomer V2.0 prediction for glucocorticoid receptor (P04150) · a predicted model of the same protein · chain C against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63104
- Every structure of UniProt P04150
- Elsewhere: RCSB PDB 6YOS · PDBe 6YOS · UniProt P63104 · UniProt P04150
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.