UniProt P04150
Glucocorticoid receptor (P04150)
Glucocorticoid receptor (UniProt P04150): 102 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 105 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P04150
- Protein
- Glucocorticoid receptor
- Experimental structures
- 102
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 105 · 24 records with a druggable one
Structures
103 records of P04150 in the MolNFT archive: 102 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1M2Z | Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain… | x-ray diffraction | A, D | — | — |
| 1M2Z | Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain… | x-ray diffraction | A, D | — | — |
| 1NHZ | Crystal Structure of the Antagonist Form of Glucocorticoid Receptor | x-ray diffraction | A | — | — |
| 1NHZ | Crystal structure of the antagonist form of glucocorticoid receptor | x-ray diffraction | A | — | — |
| 1P93 | Crystal structure of the agonist form of glucocorticoid receptor | x-ray diffraction | A, B, C, D | — | — |
| 1P93 | Crystal structure of the agonist form of glucocorticoid receptor | x-ray diffraction | A, B, C, D | — | — |
| 3BQD | Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol | x-ray diffraction | A | — | — |
| 3BQD | Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol | x-ray diffraction | A | — | — |
| 3CLD | Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate | x-ray diffraction | A, B | — | — |
| 3CLD | Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate | x-ray diffraction | A, B | — | — |
| 3E7C | Glucocorticoid Receptor LBD bound to GSK866 | x-ray diffraction | A, B | — | — |
| 3E7C | Glucocorticoid receptor lbd bound to GSK866 | x-ray diffraction | A, B | — | — |
| 3H52 | Crystal structure of the antagonist form of human glucocorticoid receptor | x-ray diffraction | A, B, C, D | — | — |
| 3H52 | Crystal structure of the antagonist form of human glucocorticoid receptor | x-ray diffraction | A, B, C, D | — | — |
| 3K22 | Glucocorticoid Receptor with Bound alaninamide 10 with TIF2 peptide | x-ray diffraction | A, B | — | — |
| 3K22 | Glucocorticoid receptor with bound alaninamide 10 with TIF2 peptide | x-ray diffraction | A, B | — | — |
| 3K23 | Glucocorticoid Receptor with Bound D-prolinamide 11 | x-ray diffraction | A, B, C | — | — |
| 3K23 | Glucocorticoid receptor with bound D-prolinamide 11 | x-ray diffraction | A, B, C | — | — |
| 4CSJ | The discovery of potent selective glucocorticoid receptor modulators, suitable for inhalation | x-ray diffraction | A | — | — |
| 4CSJ | The discovery of potent selective glucocorticoid receptor modulators, suitable for inhalation | x-ray diffraction | A | — | — |
| 4HN5 | GR DNA Binding Domain - TSLP nGRE Complex | x-ray diffraction | A, B | — | — |
| 4HN5 | Gr DNA binding domain - tslp ngre complex | x-ray diffraction | A, B | — | — |
| 4HN6 | GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex | x-ray diffraction | A, B | — | — |
| 4HN6 | Gr DNA binding domain R460D/D462R - tslp ngre complex | x-ray diffraction | A, B | — | — |
| 4LSJ | Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Bound to a Dibenzoxapine… | x-ray diffraction | A | — | — |
| 4LSJ | Crystal structure of the glucocorticoid receptor ligand binding domain bound to a dibenzoxapine… | x-ray diffraction | A | — | — |
| 4MDD | Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals… | x-ray diffraction | A, B | — | — |
| 4MDD | Crystal structure of the glucocorticoid receptor bound to a non- steroidal antagonist reveals… | x-ray diffraction | A, B | — | — |
| 4P6W | Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain | x-ray diffraction | A | — | — |
| 4P6W | Crystal structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain | x-ray diffraction | A | — | — |
| 4P6X | Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain | x-ray diffraction | A, C, E, G, I, K | — | — |
| 4P6X | Crystal structure of cortisol-bound glucocorticoid receptor ligand binding domain | x-ray diffraction | A, C, E, G, I, K | — | — |
| 4UDC | GR in complex with dexamethasone | x-ray diffraction | A | — | — |
| 4UDC | Gr in complex with dexamethasone | x-ray diffraction | A | — | — |
| 4UDD | GR in complex with desisobutyrylciclesonide | x-ray diffraction | A | — | — |
| 4UDD | Gr in complex with desisobutyrylciclesonide | x-ray diffraction | A | — | — |
| 5CC1 | S425G glucocorticoid receptor DNA binding domain - (+)gre complex | x-ray diffraction | A, B, W, X | — | — |
| 5E69 | Glucocorticoid receptor DNA binding domain - IL8 NF-kB response element complex | x-ray diffraction | A, B | ZN | — |
| 5E69 | Glucocorticoid receptor DNA binding domain - IL8 nf-kb response element complex | x-ray diffraction | A, B | — | — |
| 5E6A | Glucocorticoid receptor DNA binding domain - PLAU NF-kB response element complex | x-ray diffraction | A, B | ZN | 2 (best 0.68) |
| 5E6A | Glucocorticoid receptor DNA binding domain - plau nf-kb response element complex | x-ray diffraction | A, B | — | — |
| 5E6B | Glucocorticoid receptor DNA binding domain - RELB NF-kB response element complex | x-ray diffraction | A, B | ZN | 3 (best 0.69) |
| 5E6B | Glucocorticoid receptor DNA binding domain - relb nf-kb response element complex | x-ray diffraction | A, B | — | — |
| 5E6C | Glucocorticoid receptor DNA binding domain - CCL2 NF-kB response element complex | x-ray diffraction | A, B | ZN | — |
| 5E6C | Glucocorticoid receptor DNA binding domain - CCL2 nf-kb response element complex | x-ray diffraction | A, B | — | — |
| 5E6D | Glucocorticoid receptor DNA binding domain - ICAM1 NF-kB response element complex | x-ray diffraction | A, B | ZN | 3 (best 0.69) |
| 5E6D | Glucocorticoid receptor DNA binding domain - ICAM1 nf-kb response element complex | x-ray diffraction | A, B | — | — |
| 5EMC | Transcription factor GRDBD and smGRE complex | x-ray diffraction | A, B | ZN | — |
| 5EMC | Transcription factor grdbd and smgre complex | x-ray diffraction | A, B | — | — |
| 5EMP | Transcription factor GRDBD and mmGRE complex | x-ray diffraction | A, B | ZN | — |
| 5EMP | Transcription factor grdbd and mmgre complex | x-ray diffraction | A, B | — | — |
| 5EMQ | Transcription factor GRDBD and GRE complex | x-ray diffraction | A, B | ZN | — |
| 5EMQ | Transcription factor grdbd and gre complex | x-ray diffraction | A, B | — | — |
| 5G3J | Discovery of New Selective Glucocorticoid Receptor Agonist Leads | x-ray diffraction | A | CPS, E7T | — |
| 5G3J | Discovery of new selective glucocorticoid receptor agonist leads | x-ray diffraction | A | — | — |
| 5G5W | Structure guided design and discovery of Indazole ethers as highly potent, non-steroidal… | x-ray diffraction | A | R8C | 2 (best 0.83) |
| 5G5W | Structure guided design and discovery of indazole ethers as highly potent, non-steroidal… | x-ray diffraction | A | — | — |
| 5NFP | Glucocorticoid Receptor in complex with budesonide | x-ray diffraction | A | CPS, 8W5 | 2 (best 0.85) |
| 5NFP | Glucocorticoid receptor in complex with budesonide | x-ray diffraction | A | CPS, 8W5 | — |
| 5NFT | Glucocorticoid Receptor in complex with AZD5423 | x-ray diffraction | A | 8W8 | — |
43 records more on the page itself.
Ligands
- ZN · Zinc ion · in 24 records
- DEX · Dexamethasone · in 4 records
- CPS · 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate · in 3 records
- 486 · 11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodec ahydro-cyclopenta[a]phenanthren-3-one · in 2 records
- 82H · Velsecorat · in 2 records
- 8W5 · (1~{S},2~{S},4~{R},6~{R},8~{S},9~{S},11~{S},12~{S}, 13~{R})-9,13-dimethyl-11-oxidanyl-8-(2-oxidanylethanoyl)-6-propyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13, 18}]icosa-14,17-dien-16-one · in 2 records
- 8W8 · 2,2,2-tris(fluoranyl)-~{N}-[(1~{R},2~{S})-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl) propan-2-yl]ethanamide · in 2 records
- B9Q · ~{N}-[(1~{R},2~{S})-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide · in 2 records
- B9T · ~{N}-[(1~{R},2~{S})-1-(2-bromanyl-4-cyano-phenoxy)-1-(2-cyclopropylpyrimidin-5-yl)propan-2-yl]-2,2-bis(fluoranyl)propanamide · in 2 records
- B9W · 2,2-bis(fluoranyl)-~{N}-[(1~{R},2~{S})-3-methyl-1-[1-(1-methyl-6-oxidanylidene-pyridin-3-yl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]propanamide · in 2 records
- HJ4 · (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-yn-1-yl)-17-hydroxy-13-methyl-1,2, 6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name) · in 2 records
- A1ACE · (4aR,4bS,5R,6aS,6bS,8R,9aR,10aR,10bR)-8-{4-[(3-aminophenyl)methyl]phenyl}-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one · in 1 record
- E7T · 5-[[(1S,2R,4R)-4-ethyl-6,7-bis(fluoranyl)-2,5-bis(oxidanyl)-2-(trifluoromethyl)-3,4-dihydro-1H-naphthalen-1-yl]amino]-1H-quinolin-2-one · in 1 record
- GW6 · (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate · in 1 record
- QJK · 5-[(2~{R})-3-(4-chlorophenyl)carbonyl-2-(4-nitrophenyl)-4-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-1-yl]-2-oxidanyl-benzoic acid · in 1 record
- R8C · 2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-yl]acetamide · in 1 record
Experiment against prediction
- 3CLD chain B against the predicted model P04150: TM-score 0.99, RMSD 0.67 Å
- 3CLD chain B against the predicted model P04150: TM-score 0.99, RMSD 0.67 Å
- 7PRX chain A against the predicted model P04150: TM-score 0.99, RMSD 0.74 Å
- 3CLD chain A against the predicted model P04150: TM-score 0.98, RMSD 0.91 Å
- 3CLD chain A against the predicted model P04150: TM-score 0.98, RMSD 0.91 Å
- 6EL7 chain A against the predicted model P04150: TM-score 0.98, RMSD 0.80 Å
- 6EL7 chain A against the predicted model P04150: TM-score 0.98, RMSD 0.80 Å
- 5NFP chain A against the predicted model P04150: TM-score 0.98, RMSD 0.80 Å
- 5NFP chain A against the predicted model P04150: TM-score 0.98, RMSD 0.80 Å
- 5G5W chain A against the predicted model P04150: TM-score 0.98, RMSD 0.81 Å
Elsewhere
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