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Ligand · GW6

GW6 · (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate

GW6, (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate (C27 H29 F3 O6 S, 538.6 g/mol), in the MolNFT structures on GenesisL1…

Component
GW6
Formula
C27 H29 F3 O6 S
Class
ligand
Structures
2
PDB entries
2

Binding sites

GW6 in 2 structures; the first of them:

  • 3CLD · Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate · GW6 A1 · binds MET560, LEU563, ASN564, LEU566, GLY567, GLN570, TRP600, MET601 and 16 more
  • 7PRV · The glucocorticoid receptor in complex with fluticasone furoate, a PGC1a coactivator… · GW6 A805 · binds MET560, LEU563, ASN564, LEU566, GLY567, GLN570, TRP600, MET601 and 15 more

Residues it binds most

MET 4, LEU 4, CYS 4, GLN 4, PHE 4, ILE 4, ALA 4, ARG 4, ASN 4, GLY 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • EDO · 1,2-ethanediol

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