Research workbench
Binary complex of 14-3-3 zeta with glucocorticoid receptor (gr) PT524 peptide
Analyse Binary complex of 14-3-3 zeta with glucocorticoid receptor (gr) PT524 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6YO8
- Type
- protein
- Length
- 961 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein ZETA/DELTA; Glucocorticoid receptor
- UniProt
- P63104, P04150
- Pockets
- 12 · best druggability 0.71
Structure
x-ray diffraction · 4 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | 14-3-3 protein ZETA/DELTA | protein | 230 | 85% helix, 0% strand | P63104 |
| C | 14-3-3 protein ZETA/DELTA | protein | 225 | 81% helix, 0% strand | P63104 |
| E, F | Glucocorticoid receptor | protein | 12 | 0% helix, 0% strand | P04150 |
| G, H | Glucocorticoid receptor | protein | 11 | 0% helix, 0% strand | P04150 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1125 | 0.71 | 0.75 | 74 | empty |
| 2 | 588 | 0.66 | 0.76 | 44 | empty |
| 3 | 205 | 0.53 | 0.77 | 24 | empty |
| 4 | 161 | 0.51 | 0.78 | 20 | empty |
| 5 | 191 | 0.50 | 0.77 | 21 | empty |
Interfaces
7 interfaces between chains.
- A–B · 1117 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 1005 Ų buried · 11 hydrogen bonds · protein-protein
- C–G · 715 Ų buried · 14 hydrogen bonds · protein-protein
- A–E · 704 Ų buried · 14 hydrogen bonds · protein-protein
- B–F · 693 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (phosphorylation).
Compared structures
- 6YO8 · Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide · the same entry in another collection · chain H against H, TM-score 1.00
- P63104 · AlphaFold monomer V2.0 prediction for 14-3-3 protein ZETA/DELTA (P63104) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63104
- Every structure of UniProt P04150
- Elsewhere: RCSB PDB 6YO8 · PDBe 6YO8 · UniProt P63104 · UniProt P04150
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