Research workbench
Imidazole glycerol phosphate synthase
Analyse Imidazole glycerol phosphate synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6YMU
- Type
- protein
- Length
- 1,340 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Imidazole glycerol phosphate synthase subunit hisf; Imidazole glycerol phosphate synthase…
- EC
- 4.3.2.10, 3.5.1.2
- UniProt
- Q9X0C6, Q9X0C8
- Pockets
- 16 · best druggability 0.84
Structure
x-ray diffraction · 5 distinct chains · 35% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Imidazole glycerol phosphate synthase subunit hisf (EC 4.3.2.10) | protein | 244 | 41% helix, 26% strand | Q9X0C6 |
| B, D | Imidazole glycerol phosphate synthase subunit hish (EC 4.3.2.10, 3.5.1.2) | protein | 200 | 28% helix, 32% strand | Q9X0C8 |
| C | Imidazole glycerol phosphate synthase subunit hisf (EC 4.3.2.10) | protein | 251 | 37% helix, 24% strand | Q9X0C6 |
| E | Imidazole glycerol phosphate synthase subunit hisf (EC 4.3.2.10) | protein | 246 | 39% helix, 26% strand | Q9X0C6 |
| F | Imidazole glycerol phosphate synthase subunit hish (EC 4.3.2.10, 3.5.1.2) | protein | 199 | 28% helix, 37% strand | Q9X0C8 |
Pockets
16 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 844 | 0.84 | 0.87 | 98 | empty |
| 2 | 165 | 0.71 | 0.90 | 20 | empty |
| 3 | 394 | 0.71 | 0.82 | 41 | empty |
| 4 | 393 | 0.64 | 0.78 | 49 | empty |
| 5 | 421 | 0.64 | 0.78 | 49 | empty |
Interfaces
7 interfaces between chains.
- A–B · 1216 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1152 Ų buried · 12 hydrogen bonds · protein-protein
- E–F · 1122 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 313 Ų buried · 3 hydrogen bonds · protein-protein
- B–F · 195 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (nonstandard).
Compared structures
- 6YMU · Imidazole Glycerol Phosphate Synthase · the same entry in another collection · chain F against F, TM-score 1.00
- Q9X0C8 · AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hish… · a predicted model of the same protein · chain B against A, TM-score 1.00
- Q9X0C6 · AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hisf… · a predicted model of the same protein · chain E against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X0C6
- Every structure of UniProt Q9X0C8
- Elsewhere: RCSB PDB 6YMU · PDBe 6YMU · UniProt Q9X0C6 · UniProt Q9X0C8
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