UniProt Q9X0C6
Imidazole glycerol phosphate synthase subunit HisF (Q9X0C6)
Imidazole glycerol phosphate synthase subunit HisF (UniProt Q9X0C6), EC 4.1.3.-, 4.3.2.10: 37 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 21 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9X0C6
- Protein
- Imidazole glycerol phosphate synthase subunit HisF
- EC
- 4.1.3.-, 4.3.2.10
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 21 · 4 records with a druggable one
Structures
38 records of Q9X0C6 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GPW | Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol… | x-ray diffraction | A, C, E | — | — |
| 1GPW | Structural evidence for ammonia tunneling across the (BETA/ALPHA)8 barrel of the imidazole glycerol… | x-ray diffraction | A, C, E | — | — |
| 1THF | Cyclase subunit of imidazoleglycerolphosphate synthase from thermotoga maritima | x-ray diffraction | D | — | — |
| 1THF | Cyclase subunit of imidazoleglycerolphosphate synthase from thermotoga maritima | x-ray diffraction | D | — | — |
| 1VH7 | Crystal structure of a cyclase subunit of imidazolglycerolphosphate synthase | x-ray diffraction | A | — | — |
| 1VH7 | Crystal structure of a cyclase subunit of imidazolglycerolphosphate synthase | x-ray diffraction | A | — | — |
| 2A0N | Crystal structure of Imidazole glycerol phosphate synthase subunit hisF (EC 4.1.3.-) (tm1036) from… | x-ray diffraction | A | — | — |
| 2A0N | Crystal structure of imidazole glycerol phosphate synthase subunit hisf (ec 4.1.3.-) (TM1036) from… | x-ray diffraction | A | — | — |
| 2LLE | Computational design of an eight-stranded (beta/alpha)-barrel from fragments of different folds | solution nmr | A | — | — |
| 2LLE | Computational design of an eight-stranded (BETA/ALPHA)-barrel from fragments of different folds | solution nmr | A | — | — |
| 2W6R | Crystal structure of an artificial (ba)8-barrel protein designed from identical half barrels | x-ray diffraction | A | — | — |
| 2W6R | Crystal structure of an artificial (BA)8-barrel protein designed from identical half barrels | x-ray diffraction | A | — | — |
| 2WJZ | Crystal structure of (HisH) K181A Y138A mutant of imidazoleglycerolphosphate synthase (HisH HisF)… | x-ray diffraction | A, C, E | — | — |
| 2WJZ | Crystal structure of (hish) K181A Y138A mutant of imidazoleglycerolphosphate synthase (hish hisf)… | x-ray diffraction | A, C, E | — | — |
| 3OG3 | Crystal structure of an artificial thermostable (BA)8-barrel protein from identical half barrels | x-ray diffraction | A | — | — |
| 3OG3 | Crystal structure of an artificial thermostable (BA)8-barrel protein from identical half barrels | x-ray diffraction | A | — | — |
| 3ZR4 | Structural evidence for ammonia tunneling across the (beta-ALPHA)8 barrel of the imidazole glycerol… | x-ray diffraction | A, C, E | — | — |
| 3ZR4 | Structural evidence for ammonia tunneling across the (beta-ALPHA)8 barrel of the imidazole glycerol… | x-ray diffraction | A, C, E | — | — |
| 4EWN | Structure of HisF-D130V+D176V with bound rCdRP | x-ray diffraction | D | — | — |
| 4EWN | Structure of hisf-D130V+D176V with bound rcdrp | x-ray diffraction | D | — | — |
| 4FX7 | Structure of Sym2 D9V+D55V+D130V+D176V | x-ray diffraction | A, B, C, D | — | — |
| 4FX7 | Structure of SYM2 D9V+D55V+D130V+D176V | x-ray diffraction | A, B, C, D | — | — |
| 4J9J | Structure of designed HisF | x-ray diffraction | A | — | — |
| 4J9J | Structure of designed hisf | x-ray diffraction | A | — | — |
| 5TQL | Crystal structure of TIM-Barrel protein HisF-C9S | x-ray diffraction | A, B | PO4 | 2 (best 0.67) |
| 5TQL | Crystal structure of tim-barrel protein hisf-C9S | x-ray diffraction | A, B | PO4 | — |
| 6RTZ | Light-regulation of imidazole glycerol phosphate synthase by interference with its allosteric… | x-ray diffraction | A | PO4 | — |
| 6RU0 | Light-regulation of imidazole glycerol phosphate synthase by interference with its allosteric… | x-ray diffraction | A, C, E | PO4 | — |
| 6VDG | Crystal Structure of the Y182A HisF Mutant from Thermotoga maritima | x-ray diffraction | A | PO4 | 1 (best 0.60) |
| 6VDG | Crystal structure of the Y182A hisf mutant from thermotoga maritima | x-ray diffraction | A | PO4 | — |
| 6YMU | Imidazole glycerol phosphate synthase | x-ray diffraction | A, C, E | — | — |
| 7AC8 | Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole… | x-ray diffraction | A, C, E | GUO, GLN, PO4 | 17 (best 0.82) |
| 7AC8 | Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole… | x-ray diffraction | A, C, E | GUO, PO4 | — |
| 7QC3 | Hisf from T. maritima | x-ray diffraction | A | — | — |
| 7QC7 | HisF-C9A-D11E-V33A_L50H_I52H mutant (apo) from T. maritima | x-ray diffraction | A | — | 1 (best 0.66) |
| 7QC9 | HisF-C9A-D11E-V33A_L50H_I52H mutant in complex with Ni(II) from T. maritima | x-ray diffraction | A | NI, SO4 | — |
| 7QC9 | Hisf-C9A-D11E-V33A_L50H_I52H mutant in complex with NI(II) from T. maritima | x-ray diffraction | A | NI, SO4 | — |
| Q9X0C6 | AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hisf (Q9X0C6) | predicted | A | — | — |
Ligands
- PO4 · Phosphate ion · in 8 records
- GUO · [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S, 5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate · in 2 records
- NI · Nickel (II) ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- GLN · Glutamine · in 1 record
Experiment against prediction
- 2WJZ chain E against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.43 Å
- 2WJZ chain E against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.43 Å
- 6VDG chain A against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.46 Å
- 6VDG chain A against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.46 Å
- 6YMU chain E against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.49 Å
- 1GPW chain A against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.65 Å
- 1GPW chain A against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.65 Å
- 6YMU chain A against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.63 Å
- 3ZR4 chain E against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.67 Å
- 3ZR4 chain E against the predicted model Q9X0C6: TM-score 0.99, RMSD 0.67 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.