UniProt Q9X0C8
Imidazole glycerol phosphate synthase subunit HisH (Q9X0C8)
Imidazole glycerol phosphate synthase subunit HisH (UniProt Q9X0C8), EC 2.4.2.-, 3.5.1.2: 18 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 57 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9X0C8
- Protein
- Imidazole glycerol phosphate synthase subunit HisH
- EC
- 2.4.2.-, 3.5.1.2, 4.3.2.10
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 57 · 6 records with a druggable one
Structures
19 records of Q9X0C8 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GPW | Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol… | x-ray diffraction | B, D, F | PO4 | 14 (best 0.76) |
| 1GPW | Structural evidence for ammonia tunneling across the (BETA/ALPHA)8 barrel of the imidazole glycerol… | x-ray diffraction | B, D, F | — | — |
| 1K9V | Structural evidence for ammonia tunelling across the (beta-alpha)8-barrel of the imidazole glycerol… | x-ray diffraction | F | — | 1 (best 0.37) |
| 1K9V | Structural evidence for ammonia tunelling across the (beta- ALPHA)8-barrel of the imidazole… | x-ray diffraction | F | — | — |
| 1KXJ | The Crystal Structure of Glutamine Amidotransferase from Thermotoga maritima | x-ray diffraction | A, B | PO4 | 3 (best 0.59) |
| 1KXJ | The crystal structure of glutamine amidotransferase from thermotoga maritima | x-ray diffraction | A, B | — | — |
| 2WJZ | Crystal structure of (HisH) K181A Y138A mutant of imidazoleglycerolphosphate synthase (HisH HisF)… | x-ray diffraction | B, D, F | — | — |
| 2WJZ | Crystal structure of (hish) K181A Y138A mutant of imidazoleglycerolphosphate synthase (hish hisf)… | x-ray diffraction | B, D, F | — | — |
| 3ZR4 | Structural evidence for ammonia tunneling across the (beta-ALPHA)8 barrel of the imidazole glycerol… | x-ray diffraction | B, D, F | — | — |
| 3ZR4 | Structural evidence for ammonia tunneling across the (beta-ALPHA)8 barrel of the imidazole glycerol… | x-ray diffraction | B, D, F | — | — |
| 6RTZ | Light-Regulation of Imidazole Glycerol Phosphate Synthase by Interference with its Allosteric… | x-ray diffraction | B | — | 3 (best 0.70) |
| 6RTZ | Light-regulation of imidazole glycerol phosphate synthase by interference with its allosteric… | x-ray diffraction | B | — | — |
| 6RU0 | Light-Regulation of Imidazole Glycerol Phosphate Synthase by Interference with its Allosteric… | x-ray diffraction | B, D, F | — | 10 (best 0.75) |
| 6RU0 | Light-regulation of imidazole glycerol phosphate synthase by interference with its allosteric… | x-ray diffraction | B, D, F | — | — |
| 6YMU | Imidazole Glycerol Phosphate Synthase | x-ray diffraction | B, D, F | — | 13 (best 0.84) |
| 6YMU | Imidazole glycerol phosphate synthase | x-ray diffraction | B, D, F | — | — |
| 7AC8 | Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole… | x-ray diffraction | B, D, F | GLN | 13 (best 0.72) |
| 7AC8 | Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole… | x-ray diffraction | B, D, F | — | — |
| Q9X0C8 | AlphaFold monomer V2.0 prediction for imidazole glycerol phosphate synthase subunit hish (Q9X0C8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6YMU chain B against the predicted model Q9X0C8: TM-score 1.00, RMSD 0.20 Å
- 6YMU chain B against the predicted model Q9X0C8: TM-score 1.00, RMSD 0.20 Å
- 6YMU chain D against the predicted model Q9X0C8: TM-score 1.00, RMSD 0.24 Å
- 2WJZ chain D against the predicted model Q9X0C8: TM-score 1.00, RMSD 0.36 Å
- 2WJZ chain D against the predicted model Q9X0C8: TM-score 1.00, RMSD 0.36 Å
- 2WJZ chain B against the predicted model Q9X0C8: TM-score 0.99, RMSD 0.39 Å
- 2WJZ chain B against the predicted model Q9X0C8: TM-score 0.99, RMSD 0.39 Å
- 6YMU chain F against the predicted model Q9X0C8: TM-score 0.99, RMSD 0.47 Å
- 6YMU chain F against the predicted model Q9X0C8: TM-score 0.99, RMSD 0.47 Å
- 1K9V chain F against the predicted model Q9X0C8: TM-score 0.99, RMSD 0.46 Å
Elsewhere
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